The role of the opioid system in binge eating disorder
Cambridge University Press
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Giuliano, C., & Cottone, P. (2015). The role of the opioid system in binge eating disorder. CNS Spectrums, 20 537-545. https://doi.org/10.1017/S1092852915000668
Binge eating disorder is characterized by excessive, uncontrollable consumption of palatable food within brief periods of time. Excessive intake of palatable food is thought to be driven by hedonic, rather than energy homeostatic mechanisms. However, reward processing does not only comprise consummatory actions; a key component is represented by the anticipatory phase directed at procuring the reward. This phase is highly influenced by environmental food-associated stimuli which can robustly enhance the desire to eat even in the absence of physiological needs. The opioid system (endogenous peptides and their receptors) has been strongly linked to the rewarding aspects of palatable food intake, and perhaps represents the key system involved in hedonic overeating. Here we review evidence suggesting that the opioid system can also be regarded as one of the systems regulating the anticipatory incentive processes preceding binge eating hedonic episodes.
CG was funded by Medical Research Council Programme Grant (no. G1002231) and PC was funded by the National Institute on Drug Abuse (NIDA/NIH, no. DA030425) and the National Institute of Mental Health (NIMH/NIH, no. MH091945).
External DOI: https://doi.org/10.1017/S1092852915000668
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248927