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dc.contributor.authorGuo, Joyce Yen
dc.contributor.authorHuhtaniska, Sannaen
dc.contributor.authorMiettunen, Joukoen
dc.contributor.authorJääskeläinen, Erikaen
dc.contributor.authorKiviniemi, Vesaen
dc.contributor.authorNikkinen, Juhaen
dc.contributor.authorMoilanen, Jani Sen
dc.contributor.authorHaapea, Marianneen
dc.contributor.authorMäki, Pirjoen
dc.contributor.authorJones, Peteren
dc.contributor.authorVeijola, Juhaen
dc.contributor.authorIsohanni, Mattien
dc.contributor.authorMurray, Grahamen
dc.description.abstractBACKGROUND: Progressive brain volume loss in schizophrenia has been reported in previous studies but its cause and regional distribution remains unclear. We investigated progressive regional brain reductions in schizophrenia and correlations with potential mediators. METHOD: Participants were drawn from the Northern Finland Birth Cohort 1966. A total of 33 schizophrenia individuals and 71 controls were MRI scanned at baseline (mean age = 34.7, SD = 0.77) and at follow-up (mean age = 43.4, SD = 0.44). Regional brain change differences and associations with clinical mediators were examined using FSL voxelwise SIENA. RESULTS: Schizophrenia cases exhibited greater progressive brain reductions than controls, mainly in the frontal and temporal lobes. The degree of periventricular brain volume reductions were predicted by antipsychotic medication exposure at the fourth ventricular edge and by the number of days in hospital between the scans (a proxy measure of relapse duration) at the thalamic ventricular border. Decline in social and occupational functioning was associated with right supramarginal gyrus reduction. CONCLUSION: Our findings are consistent with the possibility that antipsychotic medication exposure and time spent in relapse partially explain progressive brain reductions in schizophrenia. However, residual confounding could also account for the findings and caution must be applied before drawing causal inferences from associations demonstrated in observational studies of modest size. Less progressive brain volume loss in schizophrenia may indicate better preserved social and occupational functions.
dc.description.sponsorshipAcademy of Finland, Medical Research Council, Sigrid Jusélius Foundation and the Signe and Ane Gyllenberg Foundation, Finland, Stanley Foundation, Brain & Behavior Research Foundation. The work was partially completed within the University of Cambridge Behavioural and Clinical Neuroscience Institute, supported by a joint award from the Medical Research Council and Wellcome Trust.
dc.rightsCreative Commons Attribution 4.0*
dc.subjectlongitudinal MRIen
dc.subjectantipsychotic medicationen
dc.titleLongitudinal regional brain volume loss in schizophrenia: relationship to antipsychotic medication and change in social functionen
dc.description.versionThis is the final version of the article. It first appeared from Elsevier via
prism.publicationNameSchizophrenia Researchen
dc.rioxxterms.funderWellcome Trust
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.contributor.orcidMurray, Graham [0000-0001-8296-1742]
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
pubs.funder-project-idMRC (G0701911)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)

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Creative Commons Attribution 4.0
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0