Amorphous metal-organic frameworks for drug delivery.
Change log
Authors
Abstract
We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.
Description
Keywords
Coordination Complexes, Drug Delivery Systems, Fluoresceins, HeLa Cells, Humans, Hydrophobic and Hydrophilic Interactions, Zirconium
Journal Title
Chem Commun (Camb)
Conference Name
Journal ISSN
1359-7345
1364-548X
1364-548X
Volume Title
51
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Sponsorship
C.A.O. thanks Becas Chile and the Cambridge Trust for funding. T.D.B. thanks Trinity Hall (University of Cambridge) for funding. D.F.-J. thanks the Royal Society (UK) for funding through a University Research Fellowship. A.K.C is grateful to the European Research Council for an Advanced Investigator Award.