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dc.contributor.authorGiacomin, Paulen
dc.contributor.authorZakrzewski, Marthaen
dc.contributor.authorCroese, Johnen
dc.contributor.authorSu, Xiaopeien
dc.contributor.authorSotillo, Javieren
dc.contributor.authorMcCann, Leisaen
dc.contributor.authorNavarro, Severineen
dc.contributor.authorMitreva, Makedonkaen
dc.contributor.authorKrause, Lutzen
dc.contributor.authorLoukas, Alexen
dc.contributor.authorCantacessi, Cinziaen
dc.identifier.citationScientific Reports 2015, 5, 13797. doi: 10.1038/srep13797en
dc.description.abstractThe intestinal microbiota plays a critical role in the development of the immune system. Recent investigations have highlighted the potential of helminth therapy for treating a range of inflammatory disorders, including celiac disease (CeD); however, the mechanisms by which helminths modulate the immune response of the human host and ameliorate CeD pathology are unknown. In this study, we investigated the potential role of alterations in the human gut microbiota in helminth-mediated suppression of an inflammatory disease. We assessed the qualitative and quantitative changes in the microbiota of human volunteers with CeD prior to and following infection with human hookworms, and following challenge with escalating doses of dietary gluten. Experimental hookworm infection of the trial subjects resulted in maintenance of the composition of the intestinal flora, even after a moderate gluten challenge. Notably, we observed a significant increase in microbial species richness over the course of the trial, which could represent a potential mechanism by which hookworms can regulate gluten-induced inflammation and maintain intestinal immune homeostasis.
dc.description.sponsorshipThis work was supported by grants 1052938 to C.C., 613718 to P.G., and 1037304 and 1020114 to A.L. from the National Health and Medical Research Council of Australia (NHMRC), and from James Cook University (FMHMS 2013 grants round) and the Isaac Newton Trust / Wellcome Trust ISSF / University of Cambridge Joint Research Grants Scheme to C.C.
dc.publisherNature Publishing Group
dc.rightsAttribution 2.0 UK: England & Wales*
dc.titleExperimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjectsen
dc.description.versionThis is the final version of the article. It first appeared from NPG via
prism.publicationNameScientific Reportsen
dc.rioxxterms.funderWellcome Trust
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
rioxxterms.typeJournal Article/Reviewen

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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales