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dc.contributor.authorBurton, Grahamen
dc.contributor.authorJauniaux, Ericen
dc.date.accessioned2015-08-11T13:19:57Z
dc.date.available2015-08-11T13:19:57Z
dc.date.issued2015-09-29en
dc.identifier.citationBurton & Jauniaux. American Journal of Obstetrics and Gynecology (2015) Vol. 213, Issue 4, Supplement, pp. S6.e1-S6.e4
dc.identifier.issn0002-9378
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/249272
dc.description.abstractDiscarded at birth, the placenta is a highly complex and fascinating organ. During the course of a pregnancy, it acts as the lungs, gut, kidneys and liver of the fetus. The placenta also has major endocrine actions that modulate maternal physiology and metabolism, and provides a safe and protective milieu in which the fetus can develop. The human placenta undergoes dramatic transformations in form and function between the first trimester, when organogenesis occurs, and the remainder of pregnancy that reflect evolutionary responses to changing oxygen concentrations in the earth’s atmosphere. Recent research indicates a more interactive dialogue between the placenta and the maternal tissues than previously recognized. The endometrial glands provide histotrophic support during the first weeks of pregnancy, and the placenta appears able to stimulate its own development by upregulating gland activity in response to endocrine signals. Extravillous trophoblast cells migrate from the placenta into the uterine wall, where they interact with cells of the maternal innate immune system. These interactions have a physiological, rather than a classical immunological, outcome, and most probably mediate remodeling of the uterine spiral arteries that supply the placenta. Furthermore, deportation of aggregates of transcriptionally active trophoblast nuclei, and the release of exosomes carrying micro-RNAs challenge our perceptions of fetal-maternal signaling and where the placental interface actually lies. Here, we reconsider definitions of the placenta in the light of these recent advances.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/*
dc.titleWhat is the placenta?en
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.ajog.2015.07.050en
prism.endingPageS6.e4
prism.publicationDate2015en
prism.publicationNameAmerican Journal of Obstetrics and Gynecologyen
prism.startingPageS6.e1
prism.volume213en
dcterms.dateAccepted2015-07-31en
rioxxterms.versionofrecord10.1016/j.ajog.2015.07.050en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-09-29en
dc.contributor.orcidBurton, Graham [0000-0001-8677-4143]
dc.identifier.eissn1097-6868
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2016-09-29


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Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales