Prospective associations between sedentary time, physical activity, fitness and cardiometabolic risk factors in people with type 2 diabetes
Long, Gráinne H
Cooper, Andrew JM
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Lamb, M., Westgate, K., Brage, S., Ekelund, U., Long, G. H., Griffin, S., Simmons, R., & et al. (2015). Prospective associations between sedentary time, physical activity, fitness and cardiometabolic risk factors in people with type 2 diabetes. Diabetologia, 59 110-120. https://doi.org/10.1007/s00125-015-3756-8
Aim: To examine the prospective associations between objectively measured physical activity energy expenditure (PAEE), sedentary time, moderate- to-vigorous-intensity physical activity (MVPA), cardiorespiratory fitness (CRF) and cardiometabolic risk factors over four years in individuals with recently diagnosed diabetes. Methods: Among 308 adults (mean age 61.0 (SD 7.2) years; 34% female) with type 2 diabetes from the ADDITION-Plus study, we measured physical activity using individually calibrated combined heart rate and movement sensing. Multivariable linear regression models were constructed to examine the associations between: baseline PAEE, sedentary time, MVPA, CRF and cardiometabolic risk factors and clustered cardiometabolic risk (CCMR) at follow-up; and change in these exposures and change in CCMR and its components over four years of follow-up. Results: Individuals who increased their PAEE between baseline and follow-up had a greater reduction in waist circumference (β=-2.84cm [95% CI -4.84, -0.85]) and CCMR (-0.17 [-0.29, -0.04]) compared to those who decreased. Compared to individuals who decreased their sedentary time, those who increased had a greater increase in waist circumference (3.20cm [0.84, 5.56]). Increases in MVPA were associated with reductions in systolic blood pressure (-6.30mmHg [-11.58, -1.03]), while increases in CRF were associated with reductions in CCMR (-0.23 [-0.40,-0.05]) and waist circumference (-3.79cm [-6.62, -0.96]). Baseline measures were generally not predictive of cardiometabolic risk at follow-up. Conclusions: Encouraging people with recently diagnosed diabetes to increase their physical activity and decrease their sedentary time may have beneficial effects on waist circumference, blood pressure and clustered cardiometabolic risk.
Cardiometabolic, cardiovascular, diabetes, fitness, intervention, physical activity, prospective, sedentary
The trial is supported by the Medical Research Council (grant reference no. G0001164), the Wellcome Trust (grant reference no. G061895), National Health Service R&D support funding (including the Primary Care Research and Diabetes Research Networks) and National Institute of Health Research under its Programme Grants for Applied Research scheme (RP-PG-0606-1259). SJG is a member of the NIHR School for Primary Care Research. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, the NIHR, or the UK Department of Health. We are grateful to Diabetes UK for providing patient information materials.
Wellcome Trust (061895/Z/00/Z)
Medical Research Council (MC_U106179474)
NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC) (HTA/08/116/300)
NIHR Central Commissioning Facility (NIHRDH-RP-PG-0606-1259)
External DOI: https://doi.org/10.1007/s00125-015-3756-8
This record's URL: https://www.repository.cam.ac.uk/handle/1810/250314
Creative Commons Attribution 4.0 International License
Licence URL: http://creativecommons.org/licenses/by/4.0/