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dc.contributor.authorLamb, Maxineen
dc.contributor.authorWestgate, Kateen
dc.contributor.authorBrage, Sorenen
dc.contributor.authorEkelund, Ulfen
dc.contributor.authorLong, Gráinne Hen
dc.contributor.authorGriffin, Simonen
dc.contributor.authorSimmons, Rebeccaen
dc.contributor.authorCooper, Andrew JMen
dc.date.accessioned2015-08-19T13:00:42Z
dc.date.available2015-08-19T13:00:42Z
dc.date.issued2015-10-30en
dc.identifier.citationDiabetologia 2016, 59(1): 110-120. doi:10.1007/s00125-015-3756-8en
dc.identifier.issn0012-186X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/250314
dc.description.abstractAim: To examine the prospective associations between objectively measured physical activity energy expenditure (PAEE), sedentary time, moderate- to-vigorous-intensity physical activity (MVPA), cardiorespiratory fitness (CRF) and cardiometabolic risk factors over four years in individuals with recently diagnosed diabetes. Methods: Among 308 adults (mean age 61.0 (SD 7.2) years; 34% female) with type 2 diabetes from the ADDITION-Plus study, we measured physical activity using individually calibrated combined heart rate and movement sensing. Multivariable linear regression models were constructed to examine the associations between: baseline PAEE, sedentary time, MVPA, CRF and cardiometabolic risk factors and clustered cardiometabolic risk (CCMR) at follow-up; and change in these exposures and change in CCMR and its components over four years of follow-up. Results: Individuals who increased their PAEE between baseline and follow-up had a greater reduction in waist circumference (β=-2.84cm [95% CI -4.84, -0.85]) and CCMR (-0.17 [-0.29, -0.04]) compared to those who decreased. Compared to individuals who decreased their sedentary time, those who increased had a greater increase in waist circumference (3.20cm [0.84, 5.56]). Increases in MVPA were associated with reductions in systolic blood pressure (-6.30mmHg [-11.58, -1.03]), while increases in CRF were associated with reductions in CCMR (-0.23 [-0.40,-0.05]) and waist circumference (-3.79cm [-6.62, -0.96]). Baseline measures were generally not predictive of cardiometabolic risk at follow-up. Conclusions: Encouraging people with recently diagnosed diabetes to increase their physical activity and decrease their sedentary time may have beneficial effects on waist circumference, blood pressure and clustered cardiometabolic risk.
dc.description.sponsorshipThe trial is supported by the Medical Research Council (grant reference no. G0001164), the Wellcome Trust (grant reference no. G061895), National Health Service R&D support funding (including the Primary Care Research and Diabetes Research Networks) and National Institute of Health Research under its Programme Grants for Applied Research scheme (RP-PG-0606-1259). SJG is a member of the NIHR School for Primary Care Research. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, the NIHR, or the UK Department of Health. We are grateful to Diabetes UK for providing patient information materials.
dc.languageEnglishen
dc.language.isoenen
dc.publisherSpringer
dc.rightsCreative Commons Attribution 4.0 International License
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCardiometabolicen
dc.subjectcardiovascularen
dc.subjectdiabetesen
dc.subjectfitnessen
dc.subjectinterventionen
dc.subjectphysical activityen
dc.subjectprospectiveen
dc.subjectsedentaryen
dc.titleProspective associations between sedentary time, physical activity, fitness and cardiometabolic risk factors in people with type 2 diabetesen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s00125-015-3756-8en
prism.endingPage120
prism.publicationDate2015en
prism.publicationNameDiabetologiaen
prism.startingPage110
prism.volume59en
dc.rioxxterms.funderMRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectidG0001164
dc.rioxxterms.projectidG061895
dc.rioxxterms.projectidRP-PG-0606-1259
dcterms.dateAccepted2015-08-18en
rioxxterms.versionofrecord10.1007/s00125-015-3756-8en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-10-30en
dc.contributor.orcidLamb, Maxine [0000-0002-1284-9912]
dc.contributor.orcidWestgate, Kate [0000-0002-0283-3562]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidGriffin, Simon [0000-0002-2157-4797]
dc.contributor.orcidSimmons, Rebecca [0000-0002-7726-8529]
dc.identifier.eissn1432-0428
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/4)
pubs.funder-project-idMRC (MC_UU_12015/3)
pubs.funder-project-idMRC (G0001164)
pubs.funder-project-idMRC (1435170)
pubs.funder-project-idWellcome Trust (061895/Z/00/Z)
pubs.funder-project-idMedical Research Council (MC_U106179474)
pubs.funder-project-idNIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC) (HTA/08/116/300)
pubs.funder-project-idNIHR Central Commissioning Facility (NIHRDH-RP-PG-0606-1259)


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Creative Commons Attribution 4.0 International License
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0 International License