Which microbial factors really are important in Pseudomonas aeruginosa infections?
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Crousilles, A., Maunders, E., Bartlett, S., Fan, C., Ukor, E., Abdelhamid, Y., Baker, Y., et al. (2015). Which microbial factors really are important in Pseudomonas aeruginosa infections?. Future Microbiology, 10 1825-1836. https://www.repository.cam.ac.uk/handle/1810/250318
Over the last two decades, tens of millions of dollars have been invested in understanding virulence in the human pathogen, Pseudomonas aeruginosa. However, the top “hits” obtained in a recent TnSeq analysis aimed at identifying those genes that are conditionally essential for infection did not include most of the known virulence factors identified in these earlier studies. Instead, it seems that P. aeruginosa faces metabolic challenges in vivo, and unless it can overcome these, it fails to thrive and is cleared from the host. In this review, we look at the kinds of metabolic pathways that the pathogen seems to find essential, and comment on how this knowledge might be therapeutically exploited.
TnSeq, RNASeq, Pseudomonas aeruginosa, infection, virulence, antimicrobial agents, metabolism, cystic fibrosis
Work in the MW laboratory is funded by the BBSRC (grant BB/M019411/1) and the EU (Marie Curie Educational Training Network “INTEGRATE”). AC is supported by the Cambridge Trusts. EM is funded by a studentship from the MRC. SB is supported by a Hershel Smith studentship. E-FU is a clinical research fellow funded by the CF Trust (UK), Papworth Hospital NHS Trust and the Wellcome Trust. YA is supported by a scholarship from the Yosef Jameel Foundation. YB is an EPSRC-funded PhD student. Work in the laboratory of AF is supported by the Wellcome Trust. Work in the DRS laboratory is supported by the EPSRC.
This record's URL: https://www.repository.cam.ac.uk/handle/1810/250318