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dc.contributor.authorDoisne, Jean-Marcen
dc.contributor.authorBalmas, Elisaen
dc.contributor.authorBoulenouar, Selmaen
dc.contributor.authorGaynor, Louise Men
dc.contributor.authorKieckbusch, Jensen
dc.contributor.authorGardner, Lucyen
dc.contributor.authorHawkes, Delia Aen
dc.contributor.authorBarbara, Cynthia Fen
dc.contributor.authorSharkey, Andrewen
dc.contributor.authorBrady, Hugh JMen
dc.contributor.authorBrosens, Jan Jen
dc.contributor.authorMoffett, Ashleyen
dc.contributor.authorColucci, Francescoen
dc.identifier.citationDoisne et al. Journal of Immunology (2015) Vol. 195 Issue 8, pp. 3937-3945. doi: 10.4049/​jimmunol.1500689
dc.description.abstractInnate lymphoid cells (ILC), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells (uNK) in placentation and fetal growth, other uterine ILCs (uILCs) are likely to play roles in uterine physiology and pathology. Here we report on the composition of uILCs in the endometrium during the luteal phase and in the decidua during early pregnancy. Whilst non-killer uILC1s and uILC2s are barely detectable in mouse and not detected in humans, a sizeable population of uILC3s is found in human endometrium and decidua, which are mostly NCR+ and partially overlap with previously described IL-22 producing uNK cells. Development of mouse uILC3 is Nfil3-independent, suggesting unique features of uILCs. Indeed, although the cytokine production profile of mouse uILCs recapitulates that described in other tissues, IL-5, IL-17 and IL-22 are constitutively produced by uILC2s and uILC3s. This study lays the foundation to understand how ILCs function in the specialized uterine mucosa, both in tissue homeostasis and barrier immunity and during pregnancy.
dc.description.sponsorshipWork supported by grants from the Wellcome Trust, the Medical Research Council, the British Heart Foundation and the Leukaemia & Lymphoma Research to FC. EB is the recipient of a Centre for Trophoblast Research Graduate Studentship. SB is the recipient of a Marie Curie FP7 Fellowship.
dc.publisherAmerican Association of Immunologists
dc.rightsAttribution 2.0 UK: England & Wales
dc.titleComposition, development and function of uterine innate lymphoid cellsen
dc.description.versionThis is the final version of the article. It first appeared from the American Association of Immunologists via​jimmunol.1500689en
prism.publicationNameJournal of Immunologyen
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderBritish Heart Foundation
dc.rioxxterms.funderLeukaemia & Lymphoma Research
dc.rioxxterms.funderMarie Curie FP7 Fellowship
dc.contributor.orcidKieckbusch, Jens [0000-0002-5930-1575]
dc.contributor.orcidSharkey, Andrew [0000-0002-5072-7748]
dc.contributor.orcidMoffett, Ashley [0000-0002-8388-9073]
dc.contributor.orcidColucci, Francesco [0000-0001-5193-6376]
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (FS/12/4/29254)
pubs.funder-project-idMRC (G0900101)
pubs.funder-project-idWellcome Trust (094073/Z/10/Z)
pubs.funder-project-idBritish Heart Foundation (PG/09/077/27964)

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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales