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dc.contributor.authorIllingworth, Josephine Len
dc.contributor.authorWatson, Peteren
dc.contributor.authorXu, Stanleyen
dc.contributor.authorManford, Marken
dc.contributor.authorRing, Howarden
dc.date.accessioned2015-08-21T14:18:07Z
dc.date.available2015-08-21T14:18:07Z
dc.date.issued2015-09-19en
dc.identifier.citationEpilepsia 2015, 56(11): 1812–1818. doi:10.1111/epi.13137
dc.identifier.issn0013-9580
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/250348
dc.description.abstractObjectives: Precipitants of seizures are often reported by patients and carers, but the accuracy of these claims remains unknown. Focussing on epilepsy in people with intellectual disability (ID), the aims of this work were to (a) identify a set of methods for assessing the validity of reported seizure triggers in individual patients and (b) undertake an initial assessment of the ease of implementation and acceptability of the method by applying it to a series of cases. Methods: Data collection materials (developed with carer involvement) consisted primarily of carer diaries of seizure and trigger occurrences. Statistical analysis of diary data was using the self-controlled case series method. Unlike previously used methods, the analysis method included a means of choosing the time window, following trigger exposure, during which changes in seizure likelihood are to be assessed. Results: The method developed was trialled in five adults with ID and epilepsy, who had a range of ID severities and living circumstances. Examples of the application of the method in two of the five cases are presented for illustrative purposes. The method was acceptable to participants and most aspects successfully implemented. Significance: This method may be useful to clinicians and researchers wishing to investigate possible triggers in individual patients with epilepsy and ID. It also supports the identification of a statistically defined time window following exposure to a precipitant, during which the risk of developing a seizure is increased. The identification of such a window has value not just in contributing to clinical management, but also in guiding future work into the mechanisms of seizure precipitation.
dc.description.sponsorshipThis study was funded by a grant to HR from Epilepsy Action: The Epilepsy Association. (Registered Charity in England (No. 234343)). SX was supported by NIH/NCRR Colorado CTSI Grant Number UL1 RR025780. HR is a member of the NIHR’s Collaboration for Leadership in Applied Health Research and Care (CLAHRC) East of England at Cambridgeshire & Peterborough NHS Foundation Trust. JI also received funding from CLAHRC East of England during preparation of the manuscript. This article presents independent research with funding from the National Institute for Health Research (NIHR). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health (UK). We would also like to thank Elizabeth Blake-Palmer for her assistance with patient recruitment, and Professor Paddy Farrington for statistical advice.
dc.languageEnglishen
dc.language.isoenen
dc.subjectEpilepsyen
dc.subjectseizureen
dc.subjectprecipitanten
dc.subjectintellectual disabilityen
dc.titleA method for identifying associations between seizures and possible trigger events in adults with intellectual disabilityen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1111/epi.13137en
prism.endingPage1818
prism.publicationDate2015en
prism.publicationNameEpilepsiaen
prism.startingPage1812
prism.volume56en
dc.rioxxterms.funderEpilepsy Action: The Epilepsy Association
dc.rioxxterms.funderNIH/NCRR Colorado CTSI
dc.rioxxterms.funderNIHR
dc.rioxxterms.funderCLAHRC East of England
dc.rioxxterms.projectidUL1 RR025780
dcterms.dateAccepted2015-08-05en
rioxxterms.versionofrecord10.1111/epi.13137en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-09-19en
dc.contributor.orcidWatson, Peter [0000-0002-9436-0693]
dc.identifier.eissn1528-1167
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2016-09-19


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