The independent probabilistic firing of transcription factors: A paradigm for clonal variability in the zebrafish retina
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Boije, H., Rulands, S., Dudczig, S., Simons, B., & Harris, W. (2015). The independent probabilistic firing of transcription factors: A paradigm for clonal variability in the zebrafish retina. Developmental Cell, 34 532-543. https://doi.org/10.1016/j.devcel.2015.08.011
Early retinal progenitor cells (RPCs) in vertebrates produce lineages that vary greatly both in terms of cell number and fate composition, yet how this variability is achieved remains unknown. One possibility is that these RPCs are individually distinct and each gives rise to a unique lineage. Another is that stochastic mechanisms play upon the determinative machinery of equipotent early RPCs to drive clonal variability. Here, we show that a simple model, based on the independent firing of key fate-influencing transcription factors can quantitatively account for the intrinsic clonal variance in the zebrafish retina, and predict the distributions of neuronal cell types in clones where one or more of these fates are made unavailable.
Stochastic, Atoh7, Ptf1a, Vsx2, Lhx1, retinal ganglion cells, amacrine cells, horizontal cells, bipolar cells, photoreceptors, Zebrafish, retina, neural progenitors, probabilistic, intrinsic, extrinsic, transcription factor
BDS and SR acknowledge the support of the Wellcome Trust (098357/Z/12/Z). WAH and HB also acknowledge the support of the Wellcome Trust (100329/Z/12/Z). HB was also supported by the Swedish Research Council (2011-7054).
WELLCOME TRUST (098357/Z/12/Z)
Wellcome Trust (100329/Z/12/Z)
External DOI: https://doi.org/10.1016/j.devcel.2015.08.011
This record's URL: https://www.repository.cam.ac.uk/handle/1810/250388
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/