Show simple item record

dc.contributor.authorBoije, Henriken
dc.contributor.authorRulands, Steffenen
dc.contributor.authorDudczig, Stefanieen
dc.contributor.authorSimons, Benjaminen
dc.contributor.authorHarris, Williamen
dc.date.accessioned2015-08-28T10:31:53Z
dc.date.available2015-08-28T10:31:53Z
dc.date.issued2015-09-03en
dc.identifier.citationBoije et al. Developmental Cell (2015) Vol. 34, Issue 5, pp. 532-543. doi: 10.1016/j.devcel.2015.08.011en
dc.identifier.issn1534-5807
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/250388
dc.description.abstractEarly retinal progenitor cells (RPCs) in vertebrates produce lineages that vary greatly both in terms of cell number and fate composition, yet how this variability is achieved remains unknown. One possibility is that these RPCs are individually distinct and each gives rise to a unique lineage. Another is that stochastic mechanisms play upon the determinative machinery of equipotent early RPCs to drive clonal variability. Here, we show that a simple model, based on the independent firing of key fate-influencing transcription factors can quantitatively account for the intrinsic clonal variance in the zebrafish retina, and predict the distributions of neuronal cell types in clones where one or more of these fates are made unavailable.
dc.description.sponsorshipBDS and SR acknowledge the support of the Wellcome Trust (098357/Z/12/Z). WAH and HB also acknowledge the support of the Wellcome Trust (100329/Z/12/Z). HB was also supported by the Swedish Research Council (2011-7054).
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectStochasticen
dc.subjectAtoh7en
dc.subjectPtf1aen
dc.subjectVsx2en
dc.subjectLhx1en
dc.subjectretinal ganglion cellsen
dc.subjectamacrine cellsen
dc.subjecthorizontal cellsen
dc.subjectbipolar cellsen
dc.subjectphotoreceptorsen
dc.subjectZebrafishen
dc.subjectretinaen
dc.subjectneural progenitorsen
dc.subjectprobabilisticen
dc.subjectintrinsicen
dc.subjectextrinsicen
dc.subjecttranscription factoren
dc.titleThe independent probabilistic firing of transcription factors: A paradigm for clonal variability in the zebrafish retinaen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.devcel.2015.08.011en
prism.endingPage543
prism.publicationDate2015en
prism.publicationNameDevelopmental Cellen
prism.startingPage532
prism.volume34en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectid098357/Z/12/Z
dc.rioxxterms.projectid100329/Z/12/Z
dcterms.dateAccepted2015-08-13en
rioxxterms.versionofrecord10.1016/j.devcel.2015.08.011en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-09-03en
dc.contributor.orcidRulands, Steffen [0000-0001-6398-1553]
dc.contributor.orcidSimons, Benjamin [0000-0002-3875-7071]
dc.contributor.orcidHarris, William [0000-0002-9995-8096]
dc.identifier.eissn1878-1551
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (098357/Z/12/Z)
pubs.funder-project-idWellcome Trust (100329/Z/12/Z)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales