Research data supporting "Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair"
Jackson, Stephen P.
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Schmidt, C. K., Galanty, Y., Sczaniecka-Clift, M., Coates, J., Jhujh, S., Demir, M., Cornwell, M., et al. (2015). Research data supporting "Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair" [Dataset]. https://www.repository.cam.ac.uk/handle/1810/250485
Complete set of graphs for gammaH2AX, 53BP1 and ubiquitin (FK2 antibody) foci/cell kinetics in response to ionising radiation (IR)- and mock-treated human U2OS cells treated with siRNAs targeting ubiquitin E2s (screening module 1; refers to Fig. 1). Complete set of DDR signalling immunoblots, generated from whole cell extracts of IR-, camptothecin- or mock-treated human U2OS cells treated with siRNAs targeting ubiquitin E2s in screening module 3 (refers to Fig. 3 and Supplementary Fig. 2).
Foci/ cell kinetics after IR, DNA repair, DNA damage response, DNA damage signalling, siRNA screen, ubiquitin, E2 enzymes
Publication Reference: https://doi.org/10.1038/ncb3260
This work was supported by the European Community Seventh Framework Programme [grant number HEALTH-F2-2010-259893], the European Research Council (DDREAM), CRUK [grant number C6946/A14492], Wellcome Trust [grant number WT092096], the German Research Foundation (DFG) [BE 5342/1-1], and the Return-to-Europe Fellowship (FEBS).
This record's URL: https://www.repository.cam.ac.uk/handle/1810/250485
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Licence URL: http://creativecommons.org/licenses/by-sa/2.0/uk/
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