Translating the effects of mTOR on secretory senescence.
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Authors
Tomimatsu, Kosuke
Narita, Masashi https://orcid.org/0000-0001-7764-577X
Abstract
Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.
Description
Keywords
Animals, Cellular Senescence, Humans, Interleukin-1alpha, Intracellular Signaling Peptides and Proteins, Models, Genetic, Protein Biosynthesis, Protein Serine-Threonine Kinases, RNA Stability, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases, Transcription, Genetic
Journal Title
Nat Cell Biol
Conference Name
Journal ISSN
1465-7392
1476-4679
1476-4679
Volume Title
17
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Cancer Research UK (C14303/A17197)