Navigating in tissue mazes: chemoattractant interpretation in complex environments
Current Opinion in Cell Biology
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Sarris, M., & Sixt, M. (2015). Navigating in tissue mazes: chemoattractant interpretation in complex environments. Current Opinion in Cell Biology, 36 93-102. https://doi.org/10.1016/j.ceb.2015.08.001
Guided cell movement is essential for development and integrity of animals and crucially involved in cellular immune responses. Leukocytes are professional migratory cells that can navigate through most types of tissues and sense a wide range of directional cues. The responses of these cells to attractants have been mainly explored in tissue culture settings. How leukocytes make directional decisions in situ, within the challenging environment of a tissue maze, is less understood. Here we review recent advances in how leukocytes sense chemical cues in complex tissue settings and make links with paradigms of directed migration in development and Dictyostelium amoebae.
This effort was supported by the Medical Research Council, UK, (MR/L019523/1 to M. Sarris) and the European Research Council (StG 281556 to M. Sixt).
Royal Society (RG170240)
External DOI: https://doi.org/10.1016/j.ceb.2015.08.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/250548
Creative Commons Attribution 4.0
Licence URL: http://creativecommons.org/licenses/by/4.0/