Navigating in tissue mazes: chemoattractant interpretation in complex environments.
Change log
Authors
Sarris, Milka https://orcid.org/0000-0001-7016-333X
Sixt, Michael
Abstract
Guided cell movement is essential for development and integrity of animals and crucially involved in cellular immune responses. Leukocytes are professional migratory cells that can navigate through most types of tissues and sense a wide range of directional cues. The responses of these cells to attractants have been mainly explored in tissue culture settings. How leukocytes make directional decisions in situ, within the challenging environment of a tissue maze, is less understood. Here we review recent advances in how leukocytes sense chemical cues in complex tissue settings and make links with paradigms of directed migration in development and Dictyostelium discoideum amoebae.
Description
Keywords
Animals, Chemotactic Factors, Chemotaxis, Humans, Leukocytes
Journal Title
Curr Opin Cell Biol
Conference Name
Journal ISSN
0955-0674
1879-0410
1879-0410
Volume Title
36
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Medical Research Council (MR/L019523/1)
Royal Society (RG170240)
Royal Society (RG170240)
This effort was supported by the Medical Research Council, UK, (MR/L019523/1 to M. Sarris) and the European Research Council (StG 281556 to M. Sixt).