Quantitative 3D analysis of bone in hip osteoarthritis using clinical computed tomography
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Turmezei, T., Treece, G., Gee, A., Fotiadou, A. F., & Poole, K. (2015). Quantitative 3D analysis of bone in hip osteoarthritis using clinical computed tomography. European Radiology https://doi.org/10.1007/s00330-015-4048-x
Objective: To assess the relationship between proximal femoral cortical bone thickness and radiological hip osteoarthritis using quantitative 3D analysis of clinical CT data. Methods: Image analysis was performed on clinical CT imaging data from 203 female volunteers with a technique called cortical bone mapping. Colour thickness maps were created for each proximal femur. Statistical parametric mapping was performed to identify statistically significant differences in cortical bone thickness that corresponded with the severity of radiological hip osteoarthritis. Kellgren and Lawrence (K&L) grade, minimum joint space width (JSW) and a novel CT-based osteophyte score were also blindly assessed from the CT data. Results: For each increase in K&L grade, cortical thickness increased by up to 25% in distinct areas of the superolateral femoral head-neck junction and superior subchondral bone plate. For increasing severity of CT osteophyte, the increase in cortical thickness was more circumferential, involving a wider portion of the head-neck junction, with up to 7% increase in cortical thickness per increment in score. Results were not significant for minimum JSW. Conclusions: These findings indicate that quantitative 3D analysis of the proximal femur can identify changes in cortical bone thickness relevant to structural hip osteoarthritis.
osteoarthritis, hip joint, bone, helical CT, imaging, three-dimensional
TT acknowledges the support of an Evelyn Trust Clinical Training Fellowship award (RG65411). KP acknowledges support of an Arthritis Research UK Research Progression award (RG66087), and the Cambridge NIHR Biomedical Research Centre (RG64245). None of the funding sources had a role in study design, data handling, writing of the report, or decision to submit the paper for publication.
Wellcome Trust (100676/Z/12/Z)
Evelyn Trust (16011)
Evelyn Trust (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
External DOI: https://doi.org/10.1007/s00330-015-4048-x
This record's URL: https://www.repository.cam.ac.uk/handle/1810/250578
Creative Commons Attribution-NonCommercial 4.0
Licence URL: http://creativecommons.org/licenses/by-nc/4.0/