An orthogonal biocatalytic approach for the safe generation and use of HCN in a multi-step continuous preparation of chiral O-acetylcyanohydrins

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dc.contributor.authorBrahma, Aischaryaen
dc.contributor.authorMusio, Biagiaen
dc.contributor.authorIsmayilova, Uliviyaen
dc.contributor.authorNikbin, Nikzaden
dc.contributor.authorKamptmann, Sonja Ben
dc.contributor.authorSiegert, Petraen
dc.contributor.authorJeromin, Günter Een
dc.contributor.authorLey, Stevenen
dc.contributor.authorPohl, Martinaen
dc.date.accessioned2015-09-16T10:00:24Z
dc.date.available2015-09-16T10:00:24Z
dc.date.issued2015-09-29en
dc.identifier.citationSynlett 2016, 27(2): 262-266. doi:10.1055/s-0035-1560644en
dc.identifier.issn0936-5214
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/250585
dc.description.abstractAn enantioselective preparation of O-acetylcyanohydrins has been accomplished by a three-step telescoped continuous process. The modular components enabled accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas, and in-line stabilization of products. This method proved to be advantageous over the batch protocols in terms of reaction time (40 vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.
dc.description.sponsorshipWe gratefully acknowledge the Deutsche Forschungsgemeinschaft (DFG) within the research training group GRK 1166 “Biocatalysis in non-conventional media (BioNoCo)”, and the EPSRC (Award Nos. EP/K009494/1 and EP/K039520/1)
dc.languageEnglishen
dc.language.isoenen
dc.publisherGeorg Thieme Verlag KG
dc.rightsCreative Commons Attribution 4.0 International License
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectArabidopsis thalianaen
dc.subjectNovozyme 435en
dc.subjectbiocatalysisen
dc.subjectflowen
dc.subjecttelescopeden
dc.subjectHCNen
dc.subjectcyanohydrinsen
dc.titleAn orthogonal biocatalytic approach for the safe generation and use of HCN in a multi-step continuous preparation of chiral O-acetylcyanohydrinsen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Georg Thieme Verlag KG via http://dx.doi.org/10.1055/s-0035-1560644en
prism.endingPage266
prism.publicationDate2015en
prism.publicationNameSynletten
prism.startingPage262
prism.volume27en
dc.rioxxterms.funderEPSRC
dc.rioxxterms.projectidEP/K009494/1
dc.rioxxterms.projectidEP/K039520/1
rioxxterms.versionofrecord10.1055/s-0035-1560644en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-09-29en
dc.contributor.orcidMusio, Biagia [0000-0001-7799-5155]
dc.contributor.orcidLey, Steven [0000-0002-7816-0042]
dc.identifier.eissn1437-2096
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/K009494/1)
pubs.funder-project-idEPSRC (EP/K039520/1)


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Creative Commons Attribution 4.0 International License
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0 International License