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dc.contributor.authorVoon, Valerieen
dc.contributor.authorBaek, Kwangyeolen
dc.contributor.authorEnander, Jesperen
dc.contributor.authorWorbe, Yuliaen
dc.contributor.authorMorris, Laurelen
dc.contributor.authorHarrison, Neil Aen
dc.contributor.authorRobbins, Trevoren
dc.contributor.authorRück, Christianen
dc.contributor.authorDaw, Nathanielen
dc.date.accessioned2015-09-21T11:16:08Z
dc.date.available2015-09-21T11:16:08Z
dc.date.issued2015-11-03en
dc.identifier.citationTranslational Psychiatry 2015, 5, e670. doi: 10.1038/tp.2015.165en
dc.identifier.issn2158-3188
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/251082
dc.description.abstractOur decisions are based on parallel and competing systems of goal-directed and habitual learning, systems which can be impaired in pathological behaviours. Here we focus on the influence of motivation and compare reward and loss outcomes in subjects with obsessive-compulsive disorder (OCD) on model-based goal-directed and model-free habitual behaviours using the two-step task. We further investigate the relationship with acquisition learning using a one-step probabilistic learning task. Forty-eight OCD subjects and 96 healthy volunteers were tested on a reward and 30 OCD subjects and 53 healthy volunteers on the loss version of the two-step task. Thirty-six OCD subjects and 72 healthy volunteers were also tested on a one-step reversal task. OCD subjects compared with healthy volunteers were less goal oriented (model-based) and more habitual (model-free) to reward outcomes with a shift towards greater model-based and lower habitual choices to loss outcomes. OCD subjects also had enhanced acquisition learning to loss outcomes on the one-step task, which correlated with goal-directed learning in the two-step task. OCD subjects had greater stay behaviours or perseveration in the one-step task irrespective of outcome. Compulsion severity was correlated with habitual learning in the reward condition. Obsession severity was correlated with greater switching after loss outcomes. In healthy volunteers, we further show that greater reward magnitudes are associated with a shift towards greater goal-directed learning further emphasizing the role of outcome salience. Our results highlight an important influence of motivation on learning processes in OCD and suggest that distinct clinical strategies based on valence may be warranted.
dc.description.sponsorshipThe study was funded through a Wellcome Trust Intermediate Clinical Fellowship for VV (093705/Z/10/Z).
dc.languageEnglishen
dc.language.isoenen
dc.publisherNPG
dc.rightsCreative Commons Attribution 4.0
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectObsessive compulsive disorderen
dc.subjectgoal-directed learningen
dc.subjecthabit learningen
dc.subjectrewarden
dc.subjectpunishmenten
dc.subjectmotivationen
dc.titleMotivation and value influences in the relative balance of goal-directed and habitual behaviours in obsessive-compulsive disorderen
dc.title.alternativeThe relative balance of goal-directed and habitual behaviours in obsessive-compulsive disorderen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from NPG via http://dx.doi.org/10.1038/tp.2015.165en
prism.numbere670en
prism.publicationDate2015en
prism.publicationNameTranslational Psychiatryen
prism.volume5en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.projectid093705/Z/10/Z
dcterms.dateAccepted2015-09-19en
rioxxterms.versionofrecord10.1038/tp.2015.165en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-03en
dc.contributor.orcidVoon, Valerie [0000-0001-6790-1776]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.identifier.eissn2158-3188
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (093705/Z/10/Z)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)


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Creative Commons Attribution 4.0
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0