New auroras on the roles of the Chromosomal Passenger Complex in cytokinesis: implications for cancer therapies
Frontiers in Oncology section Molecular and Cellular Oncology
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D'Avino, P., & Capalbo, L. (2015). New auroras on the roles of the Chromosomal Passenger Complex in cytokinesis: implications for cancer therapies. Frontiers in Oncology section Molecular and Cellular Oncology, 5 (221)https://doi.org/10.3389/fonc.2015.00221
The Chromosomal Passenger Complex (CPC), composed of a kinase component, Aurora B, the scaffolding subunit Inner Centromeric Protein (INCENP), Borealin, and Survivin, is a key regulator of cell division. It controls multiple events, from chromosome condensation in prophase to the final separation or abscission of the two daughter cells. The essential functions of the CPC during metaphase, however, have always hindered an accurate study of its role during cytokinesis. The recent development of small molecule inhibitors against Aurora B and the use of elegant technologies such as chemical genetics have offered new approaches to study the functions of the CPC at the end of cell division. Here we review the recent findings about the roles of the CPC in controlling the assembly of the cleavage furrow, central spindle and midbody. We will also discuss the crucial function of this complex in controlling abscission timing in order to prevent abscission when lagging chromatin is present at the cleavage site, thereby avoiding the formation of genetically abnormal daughter cells. Finally, we offer our perspective on how to exploit the potential therapeutic applications of inhibiting CPC activity during cytokinesis in cancer cells.
cell division, microtubule, Aurora B, abscission, anti-cancer therapies
Research studying the role of the CPC in cytokinesis in our lab was supported by a CR-UK project grant (C12296/A12541). PPD is a recipient of a Maplethorpe Fellowship from Murray Edwards College, Cambridge.
External DOI: https://doi.org/10.3389/fonc.2015.00221
This record's URL: https://www.repository.cam.ac.uk/handle/1810/251233
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Licence URL: http://creativecommons.org/licenses/by/4.0/