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dc.contributor.authorLongdon, Benen
dc.contributor.authorMurray, Gemmaen
dc.contributor.authorPalmer, William Jen
dc.contributor.authorDay, Jonathanen
dc.contributor.authorParker, Darren Jen
dc.contributor.authorWelch, Johnen
dc.contributor.authorDarren, Obbard Jen
dc.contributor.authorJiggins, Francisen
dc.date.accessioned2015-09-30T13:42:09Z
dc.date.available2015-09-30T13:42:09Z
dc.date.issued2015en
dc.identifier.citationVirus Evolution 2015, 1(1): vev014. doi: 10.1093/ve/vev014en
dc.identifier.issn2057-1577
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/251258
dc.description.abstractMetagenomic studies are leading to the discovery of a hidden diversity of RNA viruses. These new viruses are poorly characterised and new approaches are needed predict the host species these viruses pose a risk to. The rhabdoviruses are a diverse family of RNA viruses that includes important pathogens of humans, animals and plants. We have discovered 32 new rhabdoviruses through a combination of our own RNA sequencing of insects and searching public sequence databases. Combining these with previously known sequences we reconstructed the phylogeny of 195 rhabdovirus sequences, and produced the most in depth analysis of the family to date. In most cases we know nothing about the biology of the viruses beyond the host they were identified from, but our dataset provides a powerful phylogenetic approach to predict which are vector- borne viruses and which are specific to vertebrates or arthropods. By reconstructing ancestral and present host states we found that switches between major groups of hosts have occurred rarely during rhabdovirus evolution. This allowed us to propose 76 new likely vector-borne vertebrate viruses among viruses identified from vertebrates or biting insects. Based on currently available data, our analysis suggests it is likely there was a single origin of the known plant viruses and arthropod-borne vertebrate viruses, while vertebrate-specific and arthropod-specific viruses arose at least twice. There are also few transitions between aquatic and terrestrial ecosystems. Viruses also cluster together at a finer scale, with closely related viruses tending to be found in closely related hosts. Our data therefore suggest that throughout their evolution, rhabdoviruses have occasionally jumped between distantly related host species before spreading through related hosts in the same environment. This approach offers a way to predict the most probable biology and key traits of newly discovered viruses.
dc.description.sponsorshipBL and FMJ are supported by a NERC grant (NE/L004232/1), a European Research Council grant (281668, DrosophilaInfection), a Junior Research Fellowship from Christ’s College, Cambridge (BL). GGRM is supported by an MRC studentship. The metagenomic sequencing of viruses from D. immigrans, D. tristis and S. deflexa was supported by a Wellcome Trust fellowship (WT085064) to DJO.
dc.languageEnglishen
dc.language.isoenen
dc.publisherOxford University Press
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectvirusen
dc.subjecthost shiften
dc.subjectarthropoden
dc.subjectinsecten
dc.subjectRhabdoviridaeen
dc.subjectMononegaviralesen
dc.titleThe evolution, diversity and host associations of rhabdovirusesen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/ve/vev014en
prism.numbervev014en
prism.publicationDate2015en
prism.publicationNameVirus Evolutionen
prism.volume1en
dc.rioxxterms.funderERC
dc.rioxxterms.funderNERC
dc.rioxxterms.funderMRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectidNE/L004232/1
dc.rioxxterms.projectid281668
dc.rioxxterms.projectidWT085064
rioxxterms.versionofrecord10.1093/ve/vev014en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015en
dc.contributor.orcidMurray, Gemma [0000-0002-9531-1711]
dc.contributor.orcidDay, Jonathan [0000-0002-4386-3020]
dc.contributor.orcidWelch, John [0000-0001-7049-7129]
dc.contributor.orcidJiggins, Francis [0000-0001-7470-8157]
dc.identifier.eissn2057-1577
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (281668)
pubs.funder-project-idNERC (NE/L004232/1)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales