The Aminoacyl-tRNA Synthetases of Drosophila melanogaster
Gharib, Walid H
Taylor & Francis
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Lu, J., Marygold, S., Gharib, W. H., & Suter, B. (2016). The Aminoacyl-tRNA Synthetases of Drosophila melanogaster. Fly, 9 53-61. https://www.repository.cam.ac.uk/handle/1810/251283
Aminoacyl-tRNA synthetases (aaRSs) ligate amino acids to their cognate tRNAs, allowing them to decode the triplet code during translation. Through different mechanisms aaRSs also perform several non-canonical functions in transcription, translation, apoptosis, angiogenesis and inflammation. Drosophila has become a preferred system to model human diseases caused by mutations in aaRS, to dissect effects of reduced translation or non-canonical activities, and to study aminoacylation and translational fidelity and pathology. However, the lack of a systematic analysis and annotation of this gene family has hampered such studies. Here, we report the identification of the entire set of aaRSs in the fly genome and we predict their activity based on experimental evidence and/or orthology. Further, we propose a new, systematic and logical nomenclature for aaRSs. We also review the research conducted on Drosophila aaRSs to date. Together, our work provides the foundation for further research in the fly aaRS field.
aminoacyl-tRNA synthetase, Drosophila gene family, translation, multifunctional protein, Charcot-Marie-Tooth neuropathy
S.J.M. is supported by the FlyBase NIH/NHGRI grant U41HG000739 (W.M. Gelbart, Harvard University, PI; N.H. Brown, University of Cambridge, coPI). J.L. was supported by Cancer Research Switzerland and a SNF grant to B.S., and by a SNSF Early Postdoc Fellowship.
This record's URL: https://www.repository.cam.ac.uk/handle/1810/251283
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