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dc.contributor.authorMorein-Zamir, Sharonen
dc.contributor.authorVoon, Valerieen
dc.contributor.authorDodds, Chrisen
dc.contributor.authorSule, Akeemen
dc.contributor.authorvan, Niekerk Janen
dc.contributor.authorSahakian, Barbaraen
dc.contributor.authorRobbins, Trevoren
dc.date.accessioned2015-10-07T16:18:14Z
dc.date.available2015-10-07T16:18:14Z
dc.date.issued2015-11-06en
dc.identifier.citationMorein-Zamir et al. Psychological Medicine (2015) Vol. 46, Issue 4, pp. 829-840. doi:10.1017/S0033291715002330en
dc.identifier.issn0033-2917
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/251364
dc.description.abstractBackground: There is evidence of executive function impairment in Obsessive Compulsive Disorder (OCD) that potentially contributes to symptom development and maintenance. Nevertheless, the precise nature of these executive impairments and their neural basis remains to be defined. Methods: We compared stopping and shifting, two key executive functions previously implicated in OCD, in the same task using functional magnetic resonance imaging (fMRI), in patients with virtually no co-morbidities compared to age-, verbal IQ- and gender matched healthy volunteers. The combined task allowed direct comparison of neural activity in stopping and shifting independent of patient sample characteristics and state variables such as arousal, learning, or current symptom expression. Results: Both OCD patients and controls exhibited right inferior frontal cortex activation during stopping, and left inferior parietal cortex activation during shifting. However, widespread under-activation across frontal-parietal areas was found in OCD patients compared with controls for shifting but not stopping. Conservative, whole–brain analyses also indicated a remarkable divergent abnormal activation in OCD in the caudate and thalamus for these two cognitive functions, with stopping-related over-activation contrasting with shift-related under-activation. Conclusions: OCD is associated with selective components of executive function, which engage similar common elements of cortico-striatal regions in different abnormal ways. The results implicate altered neural activation of subcortical origin in executive function abnormalities in OCD that are dependent on the precise cognitive and contextual requirements, informing current theories of symptom expression.
dc.description.sponsorshipThis research was funded by a Wellcome Trust grant (089589/Z/09/Z) awarded to TW Robbins, BJ Everitt, AC Roberts, JW Dalley and BJ Sahakian. Work was completed at the Behavioural and Clinical Neuroscience Institute which is supported by a joint award from the Medical Research Council and Wellcome Trust (G00001354).
dc.languageEnglishen
dc.language.isoenen
dc.publisherCambridge University Press
dc.rightsCreative Commons Attribution 4.0 International License
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectOCDen
dc.subjectfMRI / functional Magnetic Resonance Imagingen
dc.subjectstoppingen
dc.subjectshiftingen
dc.subjectcognitive flexibilityen
dc.subjectresponse inhibitionen
dc.titleDivergent subcortical activity for distinct executive functions: stopping and shifting in obsessive compulsive disorderen
dc.title.alternativeDivergent executive functioning in OCDen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Cambridge University Press via http://dx.doi.org/10.1017/S0033291715002330en
prism.endingPage840
prism.publicationDate2015en
prism.publicationNamePsychological Medicineen
prism.startingPage829
prism.volume46en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.projectid089589/Z/09/Z
dc.rioxxterms.projectidG00001354
rioxxterms.versionofrecord10.1017/S0033291715002330en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-06en
dc.contributor.orcidVoon, Valerie [0000-0001-6790-1776]
dc.contributor.orcidSahakian, Barbara [0000-0001-7352-1745]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.identifier.eissn1469-8978
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/J012084/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
pubs.funder-project-idWellcome Trust (089589/Z/09/Z)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
pubs.funder-project-idWELLCOME TRUST (104631/Z/14/Z)


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Creative Commons Attribution 4.0 International License
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0 International License