Show simple item record

dc.contributor.authorJoshi, Francis Ren
dc.contributor.authorRajani, Nikil Ken
dc.contributor.authorAbt, Markusen
dc.contributor.authorWoodward, Marken
dc.contributor.authorBucerius, Janen
dc.contributor.authorMani, Venkateshen
dc.contributor.authorTawakol, Ahmeden
dc.contributor.authorKallend, Daviden
dc.contributor.authorFayad, Zahi Aen
dc.contributor.authorRudd, Jamesen
dc.date.accessioned2015-10-08T10:41:14Z
dc.date.available2015-10-08T10:41:14Z
dc.date.issued2016-01-04en
dc.identifier.citationJoshi et al. Journal of the American College of Cardiology (2016) Vol. 67, Issue 1, pp. 69-78. doi: 10.1016/j.jacc.2015.10.050en
dc.identifier.issn0735-1097
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/251370
dc.description.abstractObjectives: We sought to investigate non-coronary vascular calcification and its influence on changes in vascular inflammation. Background: Atherosclerosis is an inflammatory condition with calcification apparent late in the disease process. The extent and progression of coronary calcification predict cardiovascular events. Relatively little is known about non-coronary vascular calcification. Methods: One hundred and thirty participants in the dal-PLAQUE study underwent fluorodeoxyglucose positron emission tomography/computed tomography at entry and at 6 months. Calcification of the ascending aorta, arch, carotid, and coronary arteries was quantified. Cardiovascular risk factors were related to arterial calcification. The influence of baseline calcification and drug therapy (dalcetrapib vs. placebo) on progression of calcification was determined. Finally, baseline calcification was related to changes in vascular inflammation. Results: Age >65 years was consistently associated with higher baseline calcium scores. Arch calcification trended to progress more in those with calcification at baseline (p = 0.055). There was no significant difference in progression of vascular calcification with dalcetrapib as compared to placebo. Average carotid target-to-background ratio indices declined over 6 months if carotid calcium was absent (single hottest slice [p = 0.037], mean of maximum target-to-background ratio [p = 0.010], and mean most diseased segment [p = <0.001]), but did not significantly change if calcification was present at baseline. Conclusions: Across multiple arterial regions, higher age is consistently associated with higher calcium scores. The presence of vascular calcification at baseline is associated with progressive calcification; in the carotid arteries, calcification appears to influence vascular inflammation. Dalcetrapib therapy did not affect vascular calcification.
dc.description.sponsorshipThe study was supported by F. Hoffmann-La Roche Ltd, Basel, Switzerland. Some editorial assistance was provided by Prime Healthcare and was funded by F. Hoffmann-La Roche Ltd, Basel, Switzerland. Partial support is acknowledged from NIH/NHLBI R01 HL071021 (ZAF). We thank Elisabetta Damonte for helping with statistical analyses.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/*
dc.subjectatherosclerosisen
dc.subjectcalciumen
dc.subjectinflammationen
dc.subjectdalcetrapiben
dc.titleDoes Vascular Calcification Accelerate Inflammation? A Sub-Study of the dal-PLAQUE Trialen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.jacc.2015.10.050en
prism.endingPage78
prism.publicationDate2016en
prism.publicationNameJournal of the American College of Cardiologyen
prism.startingPage69
prism.volume67en
dc.rioxxterms.funderNIH
dcterms.dateAccepted2015-10-07en
rioxxterms.versionofrecord10.1016/j.jacc.2015.10.050en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-01-04en
dc.contributor.orcidRudd, James [0000-0003-2243-3117]
dc.identifier.eissn1558-3597
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (PG/09/083/27667)
pubs.funder-project-idBritish Heart Foundation (FS/12/29/29463)
rioxxterms.freetoread.startdate2017-01-04


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales