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dc.contributor.authorThorne, Lucyen
dc.contributor.authorArias, Armandoen
dc.contributor.authorGoodfellow, Ianen
dc.date.accessioned2015-10-12T16:34:37Z
dc.date.available2015-10-12T16:34:37Z
dc.date.issued2016en
dc.identifier.citationJournal of Infectious Diseases 2016, 213(suppl 1): S27-S31. doi:10.1093/infdis/jiv280en
dc.identifier.issn0022-1899
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/251396
dc.description.abstractHuman noroviruses are a leading cause of gastroenteritis worldwide, yet there are no licenced antivirals. There is an urgent need for norovirus therapeutics, particularly for chronic infections in the immunocompromised, but also potentially for prophylactic use in epidemics. Continued research has led to the identification of compounds that inhibit norovirus replication in vitro and, at least in some cases, are also effective in vivo against murine norovirus. Progress has ranged from classical approaches targeting viral proteins and harnessing the antiviral action of interferon, to targeting essential host cell factors and to novel strategies exploiting the high mutation rate of noroviruses.
dc.description.sponsorshipThe authors declare no conflict in interest. This work was supported by the Wellcome Trust (Ref: WT097997MA)
dc.languageEnglishen
dc.language.isoenen
dc.publisherOxford University Press
dc.rightsCreative Commons Attribution 4.0 International License
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHuman norovirusen
dc.subjectantiviralsen
dc.subjectproteaseen
dc.subjectpolymeraseen
dc.subjectinterferon λen
dc.subjectfavipiraviren
dc.subjectlethal mutagenesisen
dc.titleAdvances towards a norovirus antiviral: from classical inhibitors to lethal mutagenesisen
dc.title.alternativeAdvances towards norovirus antiviralsen
dc.typeArticle
dc.description.versionThis is the final version of the article. It was first available from Oxford University Press via http://dx.doi.org/10.1093/infdis/jiv280en
prism.endingPageS31
prism.publicationDate2016en
prism.publicationNameThe Journal of Infectious Diseasesen
prism.startingPageS27
prism.volume213en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectidWT097997MA
rioxxterms.versionofrecord10.1093/infdis/jiv280en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016en
dc.contributor.orcidGoodfellow, Ian [0000-0002-9483-510X]
dc.identifier.eissn1537-6613
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (100891/Z/13/Z)
pubs.funder-project-idWellcome Trust (097997/Z/11/Z)


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Creative Commons Attribution 4.0 International License
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0 International License