Dynamic flow synthesis of porous organic cages

Briggs, Michael E; Slater, Anna G; Lunt, Neil; Jiang, Shan; Little, Marc A; Greenaway, Rebecca L; Hasell, Tom; Battilocchio, Claudio; Ley, Steven; Cooper, Andrew I

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Authors

Briggs, Michael E

Slater, Anna G

Lunt, Neil

Jiang, Shan

Little, Marc A

Greenaway, Rebecca L

Hasell, Tom

Publication Date

2015-10-07

Journal Title

Chemical Communications

ISSN

1359-7345

Publisher

RSC

Volume

Pages

17390-1739017393

Language

English

Type

Article

Metadata

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Citation

Briggs, M. E., Slater, A. G., Lunt, N., Jiang, S., Little, M. A., Greenaway, R. L., Hasell, T., et al. (2015). Dynamic flow synthesis of porous organic cages. Chemical Communications, 51 17390-1739017393. https://doi.org/10.1039/C5CC07447A

Abstract

The dynamic covalent synthesis of two imine-based porous organic cages was successfully transferred from batch to continuous flow. The same flow reactor was then used to scramble the constituents of these two cages in differing ratios to form cage mixtures. Preparative HPLC purification of one of these mixtures allowed rapid access to a desymmetrised cage molecule.

Sponsorship

We thank the Engineering and Physical Sciences Research Council (EPSRC) for financial support under the Grants EP/H000925/1 (AIC), EP/K009494/1 (SVL) and EP/M004120/1 (SVL), and Pfizer Worldwide Research & Development (CB). The authors would like to thank EPSRC Dial-a-Molecule Grand Challenge Network (EP/K004840/1) for funding a placement with SVL via the Interdisciplinary Mobility Funding scheme (AGS).

Funder references

EPSRC (EP/M004120/1)

EPSRC (EP/K009494/1)

Identifiers

External DOI: https://doi.org/10.1039/C5CC07447A

This record's URL: https://www.repository.cam.ac.uk/handle/1810/251408

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