Dynamic flow synthesis of porous organic cages
Briggs, Michael E
Slater, Anna G
Little, Marc A
Greenaway, Rebecca L
Cooper, Andrew I
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Briggs, M. E., Slater, A. G., Lunt, N., Jiang, S., Little, M. A., Greenaway, R. L., Hasell, T., et al. (2015). Dynamic flow synthesis of porous organic cages. Chemical Communications, 51 17390-1739017393. https://doi.org/10.1039/C5CC07447A
The dynamic covalent synthesis of two imine-based porous organic cages was successfully transferred from batch to continuous flow. The same flow reactor was then used to scramble the constituents of these two cages in differing ratios to form cage mixtures. Preparative HPLC purification of one of these mixtures allowed rapid access to a desymmetrised cage molecule.
We thank the Engineering and Physical Sciences Research Council (EPSRC) for financial support under the Grants EP/H000925/1 (AIC), EP/K009494/1 (SVL) and EP/M004120/1 (SVL), and Pfizer Worldwide Research & Development (CB). The authors would like to thank EPSRC Dial-a-Molecule Grand Challenge Network (EP/K004840/1) for funding a placement with SVL via the Interdisciplinary Mobility Funding scheme (AGS).
External DOI: https://doi.org/10.1039/C5CC07447A
This record's URL: https://www.repository.cam.ac.uk/handle/1810/251408