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dc.contributor.authorBrain, Kirsty Len
dc.contributor.authorAllison, Beth Jen
dc.contributor.authorNiu, Youguoen
dc.contributor.authorCross, Christine Men
dc.contributor.authorItani, Nozomien
dc.contributor.authorKane, Andrew Den
dc.contributor.authorHerrera, Emilio Aen
dc.contributor.authorGiussani, Dinoen
dc.date.accessioned2015-10-21T14:24:12Z
dc.date.available2015-10-21T14:24:12Z
dc.date.issued2015-12-10en
dc.identifier.citationPhysiological Reports 2015, 3: e12614. doi:10.14814/phy2.12614en
dc.identifier.issn2051-817X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252355
dc.description.abstractProgress in the study of pregnancy complicated by chronic hypoxia in large mammals has been held back by the inability to measure long-term significant reductions in fetal oxygenation at values similar to those measured in human pregnancy complicated by fetal growth restriction. Here, we introduce a technique for physiological research able to maintain chronically instrumented maternal and fetal sheep for prolonged periods of gestation under significant and controlled isolated chronic hypoxia beyond levels that can be achieved by habitable high altitude. This model of chronic hypoxia permits measurement of materno-fetal blood gases as the challenge is actually occurring. Chronic hypoxia of this magnitude and duration using this model recapitulates the significant asymmetric growth restriction, the pronounced cardiomyopathy and the loss of endothelial function measured in offspring of high risk pregnancy in humans, opening a new window of therapeutic research.
dc.description.sponsorshipThis work was supported by The British Heart Foundation and The Royal Society. DG is Professor of Cardiovascular Physiology & Medicine at the Department of Physiology Development & Neuroscience at the University of Cambridge, Professorial Fellow and Director of Studies in Medicine at Gonville & Caius College, a Lister Institute Fellow and a Royal Society Wolfson Research Merit Award Holder.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsCreative Commons Attribution 4.0 International License
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChronic Hypoxiaen
dc.subjectFetusen
dc.subjectPregnancyen
dc.subjectCardiovascularen
dc.titleInduction of Controlled Hypoxic Pregnancy in Large Mammalian Speciesen
dc.typeArticle
dc.description.versionThis is the final version of the article. It was first available from the American Physiological Society via http://dx.doi.org/10.14814/phy2.12614en
prism.numbere12614en
prism.publicationDate2015en
prism.publicationNamePhysiological Reportsen
prism.volume3en
dc.rioxxterms.funderBHF
rioxxterms.versionofrecord10.14814/phy2.12614en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-12-10en
dc.contributor.orcidGiussani, Dino [0000-0002-1308-1204]
dc.identifier.eissn2051-817X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (RG/06/006/22028)
pubs.funder-project-idBritish Heart Foundation (RG/11/16/29260)
pubs.funder-project-idBBSRC (BB/E002668/1)


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Creative Commons Attribution 4.0 International License
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0 International License