Mechanisms of fate decision and lineage commitment during haematopoiesis
Immunology and Cell Biology
Nature Publishing Group
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Cvejic, A. (2015). Mechanisms of fate decision and lineage commitment during haematopoiesis. Immunology and Cell Biology, 94 230-235. https://doi.org/10.1038/icb.2015.96
Blood stem cells need to both perpetuate themselves (self-renew) and differentiate into all mature blood cells to maintain blood formation throughout life. However, it is unclear how the underlying gene regulatory network maintains this population of self-renewing and differentiating stem cells and how it accommodates the transition from a stem cell to a mature blood cell. Our current knowledge of transcriptomes of various blood cell types has mainly been advanced by population-level analysis. However, a population of seemingly homogenous blood cells may include many distinct cell types with substantially different transcriptomes and abilities to make diverse fate decisions. Therefore, understanding the cell-intrinsic differences between individual cells is necessary for a deeper understanding of the molecular basis of their behaviour. Here we review recent single-cell studies in the haematopoietic system and their contribution to our understanding of the mechanisms governing cell fate choices and lineage commitment.
External DOI: https://doi.org/10.1038/icb.2015.96
This record's URL: https://www.repository.cam.ac.uk/handle/1810/252388