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dc.contributor.authorCvejic, Anaen
dc.date.accessioned2015-10-22T15:26:34Z
dc.date.available2015-10-22T15:26:34Z
dc.date.issued2015-11-17en
dc.identifier.citationCvejic. Immunology and Cell Biology (2015) Vol. 94, pp. 230-235. doi:10.1038/icb.2015.96en
dc.identifier.issn0818-9641
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252388
dc.description.abstractBlood stem cells need to both perpetuate themselves (self-renew) and differentiate into all mature blood cells to maintain blood formation throughout life. However, it is unclear how the underlying gene regulatory network maintains this population of self-renewing and differentiating stem cells and how it accommodates the transition from a stem cell to a mature blood cell. Our current knowledge of transcriptomes of various blood cell types has mainly been advanced by population-level analysis. However, a population of seemingly homogenous blood cells may include many distinct cell types with substantially different transcriptomes and abilities to make diverse fate decisions. Therefore, understanding the cell-intrinsic differences between individual cells is necessary for a deeper understanding of the molecular basis of their behaviour. Here we review recent single-cell studies in the haematopoietic system and their contribution to our understanding of the mechanisms governing cell fate choices and lineage commitment.
dc.languageEnglishen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.titleMechanisms of fate decision and lineage commitment during haematopoiesisen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/icb.2015.96en
prism.endingPage235
prism.publicationDate2015en
prism.publicationNameImmunology and Cell Biologyen
prism.startingPage230
prism.volume94en
dcterms.dateAccepted2015-10-19en
rioxxterms.versionofrecord10.1038/icb.2015.96en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-17en
dc.contributor.orcidCvejic, Ana [0000-0003-3204-9311]
dc.identifier.eissn1440-1711
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2016-05-17


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