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dc.contributor.authorMeek, Claireen
dc.contributor.authorLewis, Hannah Ben
dc.contributor.authorVergese, Bensien
dc.contributor.authorPark, Adrianen
dc.contributor.authorReimann, Franken
dc.contributor.authorGribble, Fionaen
dc.date.accessioned2015-11-10T17:58:29Z
dc.date.available2015-11-10T17:58:29Z
dc.date.issued2015-11-02en
dc.identifier.citationMeek et al. Peptides (2015) Vol. 77, pp. 38-46. doi: 10.1016/j.peptides.2015.10.008en
dc.identifier.issn0196-9781
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252574
dc.description.abstractCONTEXT: Weight loss and improved blood glucose control after bariatric surgery have been attributed in part to increased ileal nutrient delivery with enhanced release of glucagon-like peptide 1 (GLP-1). Non-surgical strategies to manage obesity are required. The aim of the current study was to assess whether encapsulated glutamine, targetted to the ileum, could increase GLP-1 secretion, improve glucose tolerance or reduce meal size. METHODS: A single-centre, randomised, double blind, placebo-controlled, cross-over study was performed in 24 healthy volunteers and 8 patients with type 2 diabetes. Fasting participants received a single dose of encapsulated ileal-release glutamine (3.6 or 6.0 g) or placebo per visit with blood sampling at baseline and for 4 hours thereafter. Glucose tolerance and meal size were studied using a 75 g oral glucose tolerance test and ad libitum meal respectively. RESULTS: In healthy volunteers, ingestion of 6.0 g glutamine was associated with increased GLP-1 concentrations after 90 min compared with placebo (mean 10.6 pg/ml vs 6.9 pg/ml, p=0.004), increased insulin concentrations after 90 min (mean 70.9 vs 48.5, p=0.048), and increased meal size at 120 min (mean 542 g eaten vs 481 g, p=0.008). Ingestion of 6.0 g glutamine was not associated with significant differences in GLP-1, glucose or insulin concentrations after a glucose tolerance test in healthy or type 2 diabetic participants. CONCLUSIONS: Single oral dosing of encapsulated glutamine did not provoke consistent increases in GLP-1 and insulin secretion and was not associated with beneficial metabolic effects in healthy volunteers or patients with type 2 diabetes.
dc.description.sponsorshipThis project was supported by a project grant from the European Union Seventh Framework Programme (FP7/2007-2013; grant agreement n° 266,408) as part of a larger collaboration called Full4Health. Claire Meek receives salary funding from the Wellcome Trust Translational Medicine and Therapeutics Programme which is funded by the Wellcome Trust in association with Glaxo SmithKline. FMG and FR were funded by the Wellcome Trust (WT088357/Z/09/Z and WT084210/Z/07/Z.)
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/*
dc.subjectGlucagon-like peptide 1en
dc.subjectinsulinen
dc.subjectnutrientsen
dc.subjectincretinen
dc.subjectglutamineen
dc.titleThe effect of encapsulated glutamine on gut peptide secretion in human volunteersen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.peptides.2015.10.008en
prism.endingPage46
prism.publicationDate2015en
prism.publicationNamePeptidesen
prism.startingPage38
prism.volume77en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectidWT088357/Z/09/Z
dc.rioxxterms.projectidWT084210/Z/07/Z
dcterms.dateAccepted2015-10-22en
rioxxterms.versionofrecord10.1016/j.peptides.2015.10.008en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-02en
dc.contributor.orcidMeek, Claire [0000-0002-4176-8329]
dc.contributor.orcidReimann, Frank [0000-0001-9399-6377]
dc.contributor.orcidGribble, Fiona [0000-0002-4232-2898]
dc.identifier.eissn1873-5169
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12012/3)
pubs.funder-project-idWellcome Trust (100574/Z/12/Z)
pubs.funder-project-idEC FP7 CP (266408)
rioxxterms.freetoread.startdate2016-11-02


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Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales
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