Molecular landscapes of human haematopoietic stem cells in health and leukaemia.
Annals of the New York Academy of Sciences
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Vedi, A., Santoro, A., Dunant, C., Dick, J. E., & Laurenti, E. (2015). Molecular landscapes of human haematopoietic stem cells in health and leukaemia.. Annals of the New York Academy of Sciences, 1370 5-14. https://doi.org/10.1111/nyas.12981
Blood cells are organized as a hierarchy with haematopoietic stem cells (HSCs) at its root. The advent of genomic technologies has opened the way for global characterization of the molecular landscape of haematopoietic stem cells and their progeny both in mouse and human models at the genetic, transcriptomic, epigenetic and proteomics level. Here we outline our current understanding of the molecular programmes that govern human HSCs and how dynamic changes occurring during HSC differentiation are necessary for well-regulated blood formation under homeostasis and upon injury. A large body of evidence is accumulating on how these programmes of normal haematopoiesis are modified in acute myeloid leukemia (AML), an aggressive adult malignancy, driven by leukemic stem cells (LSCs). Here we summarise these findings and their clinical implications.
haematopoietic stem cells, acute myeloid leukemia, transcriptomics, epigenetics
The authors would like to thank Emily Calderbank for critical review of the manuscript. Research in EL laboratory is supported by a Wellcome Trust Sir Henry Dale Fellowship and core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute.
WELLCOME TRUST (107630/Z/15/Z)
External DOI: https://doi.org/10.1111/nyas.12981
This record's URL: https://www.repository.cam.ac.uk/handle/1810/252601