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dc.contributor.authorVedi, Aditien
dc.contributor.authorSantoro, Antonellaen
dc.contributor.authorDunant, Cyrilleen
dc.contributor.authorDick, John Een
dc.contributor.authorLaurenti, Elisaen
dc.date.accessioned2015-11-13T13:29:34Z
dc.date.available2015-11-13T13:29:34Z
dc.date.issued2015-12-11en
dc.identifier.citationAnnals of the New York Academy of Sciences 2015. doi:10.1111/nyas.12981en
dc.identifier.issn0077-8923
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252601
dc.description.abstractBlood cells are organized as a hierarchy with haematopoietic stem cells (HSCs) at its root. The advent of genomic technologies has opened the way for global characterization of the molecular landscape of haematopoietic stem cells and their progeny both in mouse and human models at the genetic, transcriptomic, epigenetic and proteomics level. Here we outline our current understanding of the molecular programmes that govern human HSCs and how dynamic changes occurring during HSC differentiation are necessary for well-regulated blood formation under homeostasis and upon injury. A large body of evidence is accumulating on how these programmes of normal haematopoiesis are modified in acute myeloid leukemia (AML), an aggressive adult malignancy, driven by leukemic stem cells (LSCs). Here we summarise these findings and their clinical implications.
dc.description.sponsorshipThe authors would like to thank Emily Calderbank for critical review of the manuscript. Research in EL laboratory is supported by a Wellcome Trust Sir Henry Dale Fellowship and core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.subjecthaematopoietic stem cellsen
dc.subjectacute myeloid leukemiaen
dc.subjecttranscriptomicsen
dc.subjectepigeneticsen
dc.titleMolecular landscapes of human haematopoietic stem cells in health and leukaemia.en
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1111/nyas.12981en
prism.endingPage14
prism.publicationDate2015en
prism.publicationNameAnnals of the New York Academy of Sciencesen
prism.startingPage5
prism.volume1370en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dcterms.dateAccepted2015-11-10en
rioxxterms.versionofrecord10.1111/nyas.12981en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-12-11en
dc.contributor.orcidDunant, Cyrille [0000-0001-5176-4439]
dc.contributor.orcidLaurenti, Elisa [0000-0002-9917-9092]
dc.identifier.eissn1749-6632
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (107630/Z/15/Z)
rioxxterms.freetoread.startdate2016-12-11


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