Brain connectivity dissociates responsiveness from drug exposure during propofol-induced transitions of consciousness
PLOS Computational Biology
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Chennu, S., O’, C. S., Adapa, R., Menon, D., & Bekinschtein, T. (2015). Brain connectivity dissociates responsiveness from drug exposure during propofol-induced transitions of consciousness. PLOS Computational Biology, 12 (e1004669)https://doi.org/10.1371/journal.pcbi.1004669
Accurately measuring the neural correlates of consciousness is a grand challenge for neuroscience. Despite theoretical advances, developing reliable brain measures to track the loss of reportable consciousness during sedation is hampered by significant individual variability in susceptibility to anaesthetics. We addressed this challenge using high-density electroencephalography to characterise changes in brain networks during propofol sedation. Assessments of spectral connectivity networks before, during and after sedation were combined with measurements of behavioural responsiveness and drug concentrations in blood. Strikingly, we found that participants who had weaker alpha band networks at baseline were more likely to become unresponsive during sedation, despite registering similar levels of drug in blood. In contrast, phase-amplitude coupling between slow and alpha oscillations correlated with drug concentrations in blood. Our findings highlight novel markers that prognosticate individual differences in susceptibility to propofol and track drug exposure. These advances could inform accurate drug titration and brain state monitoring during anaesthesia.
Host Item: http://dx.doi.org/10.1371/journal.pcbi.1004669
This work was supported by grants from the James S. McDonnell Foundation, the Wellcome Trust [WT093811MA to TAB], and the British Oxygen Professorship from the Royal College of Anaesthetists [to DKM]. The research was also supported by the NIHR Brain Injury Healthcare Technology Co-operative based at Cambridge University Hospitals NHS Foundation Trust and University of Cambridge. The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR or the UK Department of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Wellcome Trust (093875/Z/10/Z)
External DOI: https://doi.org/10.1371/journal.pcbi.1004669
This record's URL: https://www.repository.cam.ac.uk/handle/1810/252764
Creative Commons Attribution 4.0 International License
Licence URL: http://creativecommons.org/licenses/by/4.0/