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dc.contributor.authorGallego Llorente, Marcosen
dc.contributor.authorJones, Eppieen
dc.contributor.authorEriksson, Andersen
dc.contributor.authorSiska, Veronikaen
dc.contributor.authorArthur, KWen
dc.contributor.authorArthur, JWen
dc.contributor.authorCurtis, MCen
dc.contributor.authorStock, Jayen
dc.contributor.authorColtorti, Men
dc.contributor.authorPieruccini, Pen
dc.contributor.authorStretton, Sen
dc.contributor.authorBrock, Fen
dc.contributor.authorHigham, Ten
dc.contributor.authorPark, Yen
dc.contributor.authorHofreiter, Men
dc.contributor.authorBradley, DGen
dc.contributor.authorBhak, Jen
dc.contributor.authorPinhasi, Ren
dc.contributor.authorManica, Andreaen
dc.date.accessioned2015-12-04T15:44:08Z
dc.date.available2015-12-04T15:44:08Z
dc.identifier.citationLlorente et al. Science (2015) Vol. 350 no. 6262, pp. 820-822. doi: 10.1126/science.aad2879en
dc.identifier.issn0036-8075
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252866
dc.description.abstractCharacterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5× coverage ancient genome of an Ethiopian male (“Mota”) who lived approximately 4500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West, and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6 to 7% Eurasian ancestry.
dc.description.sponsorshipA.M. was supported by European Research Council (ERC) Consolidator Grant 647787 “LocalAdaptation”; R.P by ERC Starting Grant 263441, “ADNABIOARC”; M.H. by ERC Consolidator Grant 310763 “GeneFlow”; J.B. by the 2014 Research Fund (1.140113.01, 1.140064.01) of UNIST (Ulsan National Institute of Science and Technology) and Geromics internal research funding; J.T.S. by ERC Consolidator Grant 617627 “ADaPt”; K.W.A. by NSF award 1027607; D.G.B. by ERC Investigator Grant 295729-CodeX; V.S. by a scholarship from the Gates Cambridge Trust; and M.G.L. by a Biotechnology and Biological Sciences Research Council (BBSRC) DTP studentship. Permission for the archaeology was given by the Ethiopian Authority for Research and Conservation of Cultural Heritage and offices of the Ministry of Culture and Tourism for the Southern Nations, Nationalities, and Peoples Region. Raw reads from Mota are available for download through the National Center for Biotechnology Information, BioProject ID PRJNA295861, and the corresponding BAM and VCF files are available at africangenome.org
dc.languageengen
dc.language.isoenen
dc.publisherAAAS
dc.subjectAfrican Continental Ancestry Groupen
dc.subjectAsiaen
dc.subjectBiological Evolutionen
dc.subjectEthiopiaen
dc.subjectEuropeen
dc.subjectGenetic Variationen
dc.subjectGenome, Humanen
dc.subjectHuman Migrationen
dc.subjectHumansen
dc.subjectMaleen
dc.titleAncient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent.en
dc.typeArticle
prism.endingPage822
prism.issueIdentifier6262en
prism.publicationNameScienceen
prism.startingPage820
prism.volume350en
dc.rioxxterms.funderBBSRC
dcterms.dateAccepted2015-09-28en
rioxxterms.versionofrecord10.1126/science.aad2879en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-09-28en
dc.contributor.orcidEriksson, Anders [0000-0003-3436-3726]
dc.contributor.orcidStock, Jay [0000-0003-0147-8631]
dc.contributor.orcidManica, Andrea [0000-0003-1895-450X]
dc.identifier.eissn1095-9203
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (617627)
pubs.funder-project-idECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (647787)
cam.issuedOnline2015-11-13en
rioxxterms.freetoread.startdate2016-04-08


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