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dc.contributor.authorChabab, Samiraen
dc.contributor.authorLescroart, Fabienneen
dc.contributor.authorRulands, Steffenen
dc.contributor.authorMathiah, Navritaen
dc.contributor.authorSimons, Benjaminen
dc.contributor.authorBlanpain, Cédricen
dc.date.accessioned2015-12-04T16:47:59Z
dc.date.available2015-12-04T16:47:59Z
dc.date.issued2016-01-05en
dc.identifier.citationChabab et al. Cell Reports (2015) Vol. 14, Issue 1, pp. 1-10. doi: 10.1016/j.celrep.2015.12.013en
dc.identifier.issn2211-1247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252872
dc.description.abstractThe heart arises from distinct sources of cardiac progenitors that independently express Mesp1 during gastrulation. The precise number of Mesp1 progenitors that are specified during the early stage of gastrulation and their clonal behavior during heart morphogenesis is currently unknown. Here, we used clonal and mosaic tracing of Mesp1 expressing cells combined with quantitative biophysical analysis of the clonal data to define the number of cardiac progenitors and their mode of growth during heart development. Our data indicate that the myocardial layer of the heart derive from ~250 Mesp1 expressing cardiac progenitors born during gastrulation. Despite arising at different time points and contributing to different heart regions, the temporally distinct cardiac progenitors present very similar clonal dynamics. These results provide insights into the number of cardiac progenitors and their mode of growth, and opens up avenues to decipher the clonal dynamics of progenitors in other organs and tissues.
dc.description.sponsorshipS.C. and N.M. are supported by fellowship of the FRS/FRIA. F.L has been supported by the EMBO longterm fellowship. B.D.S. and S.R. are supported by Wellcome Trust (grant number 098357/Z/12/Z). C.B. is an investigator of WELBIO. This work was supported by the FNRS, the ULB foundation, the European Research Council (ERC), and the foundation Bettencourt Schueller (C.B. and F.L.).
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.titleUncovering the number and clonal dynamics of Mesp1 progenitors during heart morphogenesisen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Elsevier/Cell Press via http://dx.doi.org/10.1016/j.celrep.2015.12.013en
prism.endingPage10
prism.publicationDate2016en
prism.publicationNameCell Reportsen
prism.startingPage1
prism.volume14en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderERC
dc.rioxxterms.projectid098357/Z/12/Z
dcterms.dateAccepted2015-11-23en
rioxxterms.versionofrecord10.1016/j.celrep.2015.12.013en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-01-05en
dc.contributor.orcidRulands, Steffen [0000-0001-6398-1553]
dc.contributor.orcidSimons, Benjamin [0000-0002-3875-7071]
dc.identifier.eissn2211-1247
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (098357/Z/12/Z)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales