Show simple item record

dc.contributor.authorVatansever, Denizen
dc.contributor.authorManktelow, Anneen
dc.contributor.authorSahakian, Barbaraen
dc.contributor.authorMenon, Daviden
dc.contributor.authorStamatakis, Emmanuelen
dc.date.accessioned2015-12-10T16:14:07Z
dc.date.available2015-12-10T16:14:07Z
dc.date.issued2015-12-09en
dc.identifier.citationVatansever et al. Brain Connectivity (2016), 6(3), pp. 201-207. doi:10.1089/brain.2015.0388en
dc.identifier.issn2158-0014
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252946
dc.description.abstractThe intra/extra dimensional set-shifting task (IED) provides a reliable assessment of cognitive flexibility, the shifting of attention to select behaviorally relevant stimuli in a given context. Impairments in this domain were previously reported in patients with altered neurotransmitters systems such as schizophrenia and Parkinson’s disease. Consequently, cortico-striatal connections were implicated in the mediation of this function. In addition, parts of the default mode network (DMN), namely the medial prefrontal and posterior cingulate/precuneus cortices, are also being progressively described in association with set-shifting paradigms. Nevertheless, a definitive link between cognitive flexibility and DMN connectivity remains to be established. To this end, we related resting state fMRI-based functional connectivity of DMN with IED task performance in a healthy population, measured outside the scanner. The results demonstrated that greater posterior cingulate cortex/precuneus (DMN) connectivity with the ventromedial striatopallidum at rest correlated with fewer total adjusted errors on the IED task. This finding points to a relationship between DMN and basal ganglia connectivity for cognitive flexibility, further highlighting this network’s potential role in adaptive human cognition.
dc.description.sponsorshipThe Evelyn Trust (RUAG/018) supported this research. Additionally, DV received funding from the Yousef Jameel Academic Program; DKM is funded by the NIHR Cambridge Biomedical Centre (RCZB/004), and an NIHR Senior Investigator Award (RCZB/014), and EAS is supported by the Stephen Erskine Fellowship Queens’ College, Cambridge. We would also like to thank Dr. Guy Williams and Victoria Lupson and the rest of the staff in the Wolfson Brain Imaging Centre (WBIC) at Addenbrooke’s Hospital for their assistance in scanning. Finally, we thank all the participants for their contribution to this study
dc.languageEnglishen
dc.language.isoenen
dc.publisherMary Ann Liebert
dc.subjectcognitive flexibilityen
dc.subjectintra/extra dimensional set-shiftingen
dc.subjectfunctional connectivityen
dc.subjectdefault mode networken
dc.subjectstriatumen
dc.subjectbasal gangliaen
dc.titleCognitive Flexibility: A Default Network and Basal Ganglia Connectivity Perspectiveen
dc.title.alternativeCognitive Flexibility: A Default Mode Perspectiveen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Mary Ann Liebert via http://dx.doi.org/10.1089/brain.2015.0388en
prism.endingPage207
prism.publicationDate2015en
prism.publicationNameBrain Connectivityen
prism.startingPage201
prism.volume6en
dcterms.dateAccepted2015-12-09en
rioxxterms.versionofrecord10.1089/brain.2015.0388en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-12-09en
dc.contributor.orcidVatansever, Deniz [0000-0002-2494-9945]
dc.contributor.orcidSahakian, Barbara [0000-0001-7352-1745]
dc.contributor.orcidMenon, David [0000-0002-3228-9692]
dc.contributor.orcidStamatakis, Emmanuel [0000-0001-6955-9601]
dc.identifier.eissn2158-0022
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
rioxxterms.freetoread.startdate2016-12-09


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record