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dc.contributor.authorFrake, Rebecca Aen
dc.contributor.authorRicketts, Thomasen
dc.contributor.authorMenzies, Fiona Men
dc.contributor.authorRubinsztein, Daviden
dc.date.accessioned2015-12-10T16:37:37Z
dc.date.available2015-12-10T16:37:37Z
dc.date.issued2015-01-02en
dc.identifier.citationFrake et al. Journal of Clinical Investigation Vol. 125, Issue 1, pp. 65-74. doi:10.1172/JCI73944en
dc.identifier.issn1742-464X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252949
dc.description.abstractMost neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.
dc.description.sponsorshipWe are grateful for support from a Wellcome Trust Principal Research Fellowship (to D.C. Rubinsztein), a Wellcome Trust/MRC Strategic Grant on Neurodegeneration (to D.C. Rubinsztein), a Sims Scholarship from the FEE Fund and JB Fund (to R.A. Frake), the NIHR Biomedical Research Centre at Addenbrooke’s Hospital, the Tau Consortium, and Alzheimer’s Research UK.
dc.languageEnglishen
dc.language.isoenen
dc.publisherAmerican Society for Clinical Investigation
dc.titleAutophagy and neurodegenerationen
dc.typeConference Object
dc.description.versionThis is the final version of the article. It first appeared from the American Society for Clinical Investigation via http://dx.doi.org/10.1172/JCI73944en
prism.publicationDate2015en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.funderNIHR
rioxxterms.versionofrecord10.1172/JCI73944en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-01-02en
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.identifier.eissn1742-4658
rioxxterms.typeConference Paper/Proceeding/Abstracten
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
pubs.funder-project-idWellcome Trust (095317/Z/11/A)


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