The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
Hodgkinson, James T
Santos, Laura Carro
Geddis, Stephen M
European Journal of Organic Chemistry
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Salvaggio, F., Hodgkinson, J. T., Santos, L. C., Geddis, S. M., Galloway, W., Welch, M., & Spring, D. (2015). The Synthesis of Quinolone Natural Products from Pseudonocardia sp.. European Journal of Organic Chemistry, 2016 434-437. https://doi.org/10.1002/ejoc.201501400
The synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp2–sp3 Suzuki-Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores. The quinolones slowed growth of E. coli and S. aureus by inducing extended lag phases.
quinolone, natural product, quorum, antibacterial, Suzuki-Miyaura
The research leading to these results has received funding from the European Reserach Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC grant agreement no [279337/DOS]. Research in the DRS lab is also supported by the Engineering and Physical Sciences Research Council, Biotechnology and BiologicalSciences Research Council, Medical Research Council, Cancer Research UK, and the Wellcome Trust. Work in the MW lab is supported by the BBSRC and MRC. JTH was supported by Trinity College Cambridge. Data accessibility: all data supporting this study are provided as Supplementary Information accompanying this paper.
Royal Society (WM150022)
European Research Council (279337)
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External DOI: https://doi.org/10.1002/ejoc.201501400
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253002
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/