The synthesis of quinolone natural products from pseudonocardia sp.
Type
Article
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Authors
Abstract
Abstract The synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp2–sp3 Suzuki–Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores. The quinolones slowed growth of E. coli and S. aureus by inducing extended lag phases.
Description
Keywords
Synthetic methods, Cross-coupling, C-C coupling, Nitrogen heterocycles, Natural products, Antibiotics
Journal Title
European Journal of Organic Chemistry
Conference Name
Journal ISSN
1434-193X
1099-0690
1099-0690
Volume Title
2016
Publisher
Wiley
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/J016012/1)
Royal Society (WM150022)
European Research Council (279337)
Royal Society (WM150022)
European Research Council (279337)
The research leading to these results has received funding from the European Reserach Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC grant agreement no [279337/DOS]. Research in the DRS lab is also supported by the Engineering and Physical Sciences Research Council, Biotechnology and BiologicalSciences Research Council, Medical Research Council, Cancer Research UK, and the Wellcome Trust. Work in the MW lab is supported by the BBSRC and MRC. JTH was supported by Trinity College Cambridge. Data accessibility: all data supporting this study are provided as Supplementary Information accompanying this paper.