Show simple item record

dc.contributor.authorLücke, Danielen
dc.contributor.authorDalton, Torynen
dc.contributor.authorLey, Stevenen
dc.contributor.authorWilson, Zoeen
dc.date.accessioned2015-12-17T17:00:24Z
dc.date.available2015-12-17T17:00:24Z
dc.identifier.citationLücke et al. Chemistry - A European Journal (2016), 22(12), pp. 4206 - 4217. doi: 10.1002/chem.201504457en
dc.identifier.issn0947-6539
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253019
dc.description.abstractFlow chemistry has been successfully integrated into the synthesis of a series of cyclooligomeric depsipeptides of three different ring sizes including the natural products beauvericin (1a), bassianolide (2b) and enniatin C (1b). A reliable flow chemistry protocol was established for the coupling and macrocyclisation to form challenging N‐methylated amides. This flexible approach has allowed the rapid synthesis of both natural and unnatural depsipeptides in high yields, enabling further exploration of their promising biological activity.
dc.description.sponsorshipThe authors gratefully acknowledge the EPSRC for financial support (grants EP/K009494/1 and EP/K039520/1).  
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectcyclooligomeric depsipeptidesen
dc.subjectnatural productsen
dc.subjectflow chemistryen
dc.subjectmacrocyclesen
dc.subjectpeptidesen
dc.titleSynthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistryen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/chem.201504457en
prism.endingPage4217
prism.publicationNameChemistry - A European Journalen
prism.startingPage4206
prism.volume22en
dc.rioxxterms.funderEPSRC
dc.rioxxterms.projectidEP/K009494/1
dc.rioxxterms.projectidEP/K039520/1
rioxxterms.versionofrecord10.1002/chem.201504457en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
dc.contributor.orcidLey, Steven [0000-0002-7816-0042]
dc.contributor.orcidWilson, Zoe [0000-0003-4606-9831]
dc.identifier.eissn1521-3765
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/K009494/1)
pubs.funder-project-idEPSRC (EP/K039520/1)
cam.orpheus.successThu Jan 30 10:20:17 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2300-01-01


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales