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dc.contributor.authorGrant, Jon Een
dc.contributor.authorLeppink, Eric Wen
dc.contributor.authorRedden, Sarah Aen
dc.contributor.authorOdlaug, Brian Len
dc.contributor.authorChamberlain, Samuel Ren
dc.date.accessioned2015-12-17T17:45:47Z
dc.date.available2015-12-17T17:45:47Z
dc.date.issued2015-05-09en
dc.identifier.citationJournal of Psychiatric Research 2015, 68: 371-376. doi:10.1016/j.jpsychires.2015.04.029en
dc.identifier.issn0022-3956
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253025
dc.description.abstractNeuropsychological studies of adults with problem gambling indicate impairments across multiple cognitive domains. Catechol-O-methyltransferase (COMT) plays a unique role in the regulation of dopamine in the prefrontal cortex, and has been implicated in the cognitive dysfunction evident in problem gambling. This study examined adults with varying levels of gambling behavior to determine whether COMT genotype was associated with differences in gambling symptoms and cognitive functioning. 260 non-treatment-seeking adults aged 18–29 years with varying degrees of gambling behavior provided saliva samples for genotyping COMT val158met (rs4680). All subjects underwent clinical evaluations and neurocognitive assessment of decision-making, working memory, and impulsivity. The Val/Val COMT genotype was associated with the largest percentage of subjects with gambling disorder (31.8%), a rate significantly different from the Val/Met (13.2%) group (p = 0.001). The Val/Val COMT group was also associated with significantly more gambling disorder diagnostic criteria being met, greater frequency of gambling behavior, and significantly worse cognitive performance on the Cambridge Gamble Task (risk adjustment and delay aversion) and the Spatial Working Memory task (total errors). This study adds to the growing literature on the role of COMT in impulsive behaviors by showing that the Val/Val genotype was associated with specific clinical and cognitive elements among young adults who gamble, in the absence of differences on demographic measures and other cognitive domains. Future work should consider using genotyping to explore whether certain polymorphisms predict subsequent development of impulsive behaviors including gambling disorder, and treatment outcomes.
dc.description.sponsorshipThis research was supported by a Center for Excellence in Gambling Research grant by the National Center for Responsible Gaming (Dr. Grant) and a research grant from the Trichotillomania Learning Center (to Mr. Odlaug).
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/*
dc.subjectDopamineen
dc.subjectCOMTen
dc.subjectPlanningen
dc.subjectCognitionen
dc.subjectImpulsivityen
dc.subjectGamblingen
dc.titleCOMT genotype, gambling activity, and cognitionen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/en
prism.endingPage376
prism.publicationDate2015en
prism.publicationNameJournal of Psychiatric Researchen
prism.startingPage371
prism.volume68en
dcterms.dateAccepted2015-04-30en
rioxxterms.versionofrecord10.1016/j.jpsychires.2015.04.029en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-05-09en
dc.identifier.eissn1879-1379
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2016-05-09


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