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dc.contributor.authorModrell, Melindaen
dc.contributor.authorHockman, Doriten
dc.contributor.authorUy, Benjaminen
dc.contributor.authorBuckley, Daviden
dc.contributor.authorSauka-Spengler, Tatjanaen
dc.contributor.authorBronner, Marianne Een
dc.contributor.authorBaker, Clareen
dc.date.accessioned2015-12-18T13:21:11Z
dc.date.available2015-12-18T13:21:11Z
dc.date.issued2013-10-25en
dc.identifier.citationDevelopmental Biology 2014, 385(2): 405-416. doi:10.1016/j.ydbio.2013.10.021en
dc.identifier.issn0012-1606
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253036
dc.description.abstractCranial neurogenic placodes and the neural crest make essential contributions to key adult characteristics of all vertebrates, including the paired peripheral sense organs and craniofacial skeleton. Neurogenic placode development has been extensively characterized in representative jawed vertebrates (gnathostomes) but not in jawless fishes (agnathans). Here, we use in vivo lineage tracing with DiI, together with neuronal differentiation markers, to establish the first detailed fate-map for placode-derived sensory neurons in a jawless fish, the sea lamprey Petromyzon marinus, and to confirm that neural crest cells in the lamprey contribute to the cranial sensory ganglia. We also show that a pan-Pax3/7 antibody labels ophthalmic trigeminal (opV, profundal) placode-derived but not maxillomandibular trigeminal (mmV) placode-derived neurons, mirroring the expression of gnathostome Pax3 and suggesting that Pax3 (and its single Pax3/7 lamprey ortholog) is a pan-vertebrate marker for opV placode-derived neurons. Unexpectedly, however, our data reveal that mmV neuron precursors are located in two separate domains at neurula stages, with opV neuron precursors sandwiched between them. The different branches of the mmV nerve are not comparable between lampreys and gnatho-stomes, and spatial segregation of mmV neuron precursor territories may be a derived feature of lampreys. Nevertheless, maxillary and mandibular neurons are spatially segregated within gnathostome mmV ganglia, suggesting that a more detailed investigation of gnathostome mmV placode development would be worthwhile. Overall, however, our results highlight the conservation of cranial peripheral sensory nervous system development across vertebrates, yielding insight into ancestral vertebrate traits.
dc.description.sponsorshipThis work was funded by the Biotechnology & Biological Sciences Research Council (Grant BB/F00818X/1 to C.V.H.B), the Wellcome Trust (Ph.D. Studentship 086804/Z/08/Z to C.V.H.B. and D.H.) and the National Institutes of Health (Grants DE017911 and DE16459 to M.E.B).
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectPlacodesen
dc.subjectNeural cresten
dc.subjectOphthalmic trigeminalen
dc.subjectProfundalen
dc.subjectMaxillomandibularen
dc.titleA fate-map for cranial sensory ganglia in the sea lampreyen
dc.typeArticle
dc.description.versionThis is the final version of the article. It was first available from Elsevier via http://dx.doi.org/10.1016/j.ydbio.2013.10.021en
prism.endingPage416
prism.publicationDate2013en
prism.publicationNameDevelopmental Biologyen
prism.startingPage405
prism.volume385en
dc.rioxxterms.funderBBSRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderNIH
dc.rioxxterms.projectidBB/F00818X/1
dc.rioxxterms.projectid086804/Z/08/Z
dc.rioxxterms.projectidDE017911
dc.rioxxterms.projectidDE16459
dcterms.dateAccepted2013-10-21en
rioxxterms.versionofrecord10.1016/j.ydbio.2013.10.021en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2013-10-25en
dc.contributor.orcidBaker, Clare [0000-0002-4434-3107]
dc.identifier.eissn1095-564X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (086804/Z/08/Z)
pubs.funder-project-idBBSRC (BB/F00818X/1)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales