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dc.contributor.authorFerreira, de Castro Karinaen
dc.contributor.authorStrakova, Andreaen
dc.contributor.authorTinucci, Costa Mirelaen
dc.contributor.authorMurchison, Elizabethen
dc.date.accessioned2015-12-21T13:43:48Z
dc.date.available2015-12-21T13:43:48Z
dc.date.issued2016-05-02en
dc.identifier.issn1476-5810
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253073
dc.description.abstractThe canine transmissible venereal tumour (CTVT) is a transmissible cancer that is spread between dogs by the allogeneic transfer of living cancer cells. The infectious agents in CTVT are the living cancer cells themselves, which are transmitted between dogs during coitus. CTVT first arose several thousand years ago and the disease has a global distribution and is frequently observed in dogs from Brazil. We evaluated the utility of a LINE-MYC quantitative PCR for diagnosis of CTVT cases in Brazil. Our analysis indicated that the LINE-MYC rearrangement was detectable in all CTVT samples but not in their corresponding hosts. This genetic assay proves to be a useful tool for providing a definitive molecular diagnosis of CTVT, which presents with varying degrees of aggressiveness and invasiveness in different host dogs and can therefore be a diagnostic challenge in some specific cases.
dc.description.sponsorshipThis work was supported by a Research Grant from the Royal Society (RG130615)
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.subjectcanine transmissible venereal tumouren
dc.subjecttransmissible canceren
dc.subjectoncologyen
dc.subjectmolecular diagnosisen
dc.subjectLINE-MYCen
dc.titleEvaluation of a genetic assay for canine transmissible venereal tumour diagnosis in Brazilen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Wiley via https://doi.org/10.1111/vco.12205en
prism.endingPage618
prism.publicationDate2016en
prism.publicationNameVeterinary and Comparative Oncologyen
prism.startingPage615
prism.volume15en
dc.rioxxterms.funderRoyal Society
dc.rioxxterms.projectidRG130615
dcterms.dateAccepted2015-11-29en
rioxxterms.versionofrecord10.1111/vco.12205en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-05-02en
dc.contributor.orcidStrakova, Andrea [0000-0001-6221-5515]
dc.contributor.orcidMurchison, Elizabeth [0000-0001-7462-8907]
dc.identifier.eissn1476-5829
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2017-05-02


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