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dc.contributor.authorRobba, Chiaraen
dc.contributor.authorBacigaluppi, Susannaen
dc.contributor.authorBragazzi, Nicola Luigien
dc.contributor.authorBilotta, Federicoen
dc.contributor.authorSekhon, Mypinder Sen
dc.contributor.authorBertuetti, Ritaen
dc.contributor.authorErcole, Arien
dc.contributor.authorBertuccio, Alessandroen
dc.contributor.authorCzosnyka, Mareken
dc.contributor.authorMatta, Basilen
dc.date.accessioned2015-12-21T16:39:15Z
dc.date.available2015-12-21T16:39:15Z
dc.date.issued2015-12-25en
dc.identifier.citationWorld Neurosurgery 2015. doi:10.1016/j.wneu.2015.12.027en
dc.identifier.issn1878-8750
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253083
dc.description.abstractBackground: Aneurysmal subarachnoid haemorrhage (aSAH) during pregnancy represents an important cause of maternal and foetal morbidity and mortality. Approaches to diagnostics and treatment are still controversial and there are only a limited number of cases described in the literature. Our study examines the management of aSAH in pregnant patients creating a case series by combining patients from our hospital records with those from the limited available literature. Methods: Cases published between January 1995 and January 2015 were studied. Chi-squared test, exact Fisher's test, and chi-squared test for trend were used for analyzing categorical data, whilst t-test and U Wilcoxon-Mann-Whitney test for continuous data. Results: 52 patients were included. The mean age was 31.47±5.80 and most patients were in their third trimester. A univariate pooled data analysis suggested that the maternal outcome may depend on mother’s age, mother’s Hunt and Hess score and Glasgow Coma Scale at arrival, treatment modality for the aneurysm, mode and timing of delivery. However, at the multivariate analysis only the presence of general complications resulted to significantly impact on maternal outcome. Conclusions: Ruptured aneurysms in pregnant patients with aSAH may be safely secured in a timely manner. The diagnostic and treatment strategy for each of these patients should consider peculiar maternal and obstetric factors and requires a multidisciplinary assessment involving obstetrics, neurosurgeons and intensivists. Considering the observed statistical power of our series, our findings should be taken with caution and should be supported by further systematic data collection.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.subjectpregnancyen
dc.subjectsubarachnoid haemorrhageen
dc.subjectdeliveryen
dc.subjectcerebral aneurysmen
dc.titleAneurysmal Subarachnoid Haemorrhage in Pregnancy - review and pooled data analysisen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.wneu.2015.12.027en
prism.endingPage398
prism.publicationDate2015en
prism.publicationNameWorld Neurosurgeryen
prism.startingPage383
prism.volume88en
dcterms.dateAccepted2015-12-03en
rioxxterms.versionofrecord10.1016/j.wneu.2015.12.027en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-12-25en
dc.contributor.orcidErcole, Ari [0000-0001-8350-8093]
dc.contributor.orcidCzosnyka, Marek [0000-0003-2446-8006]
dc.identifier.eissn1878-8769
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2016-12-25


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