Show simple item record

dc.contributor.authorTarkin, Jason M
dc.contributor.authorDweck, Marc R
dc.contributor.authorEvans, Nicholas R
dc.contributor.authorTakx, Richard AP
dc.contributor.authorBrown, Adam J
dc.contributor.authorTawakol, Ahmed
dc.contributor.authorFayad, Zahi A
dc.contributor.authorRudd, James HF
dc.date.accessioned2015-12-23T11:07:49Z
dc.date.available2015-12-23T11:07:49Z
dc.date.issued2016-02-19
dc.identifier.citationTarkin et al. Circulation Research (2016) Vol. 118, pp. 750-769. doi: 10.1161/CIRCRESAHA.115.306247
dc.identifier.issn0009-7330
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253096
dc.description.abstractAdvances in atherosclerosis imaging technology and research have provided a range of diagnostic tools to characterize high-risk plaque in vivo; however, these important vascular imaging methods additionally promise great scientific and translational applications beyond this quest. When combined with conventional anatomic- and hemodynamic-based assessments of disease severity, cross-sectional multimodal imaging incorporating molecular probes and other novel noninvasive techniques can add detailed interrogation of plaque composition, activity, and overall disease burden. In the catheterization laboratory, intravascular imaging provides unparalleled access to the world beneath the plaque surface, allowing tissue characterization and measurement of cap thickness with micrometer spatial resolution. Atherosclerosis imaging captures key data that reveal snapshots into underlying biology, which can test our understanding of fundamental research questions and shape our approach toward patient management. Imaging can also be used to quantify response to therapeutic interventions and ultimately help predict cardiovascular risk. Although there are undeniable barriers to clinical translation, many of these hold-ups might soon be surpassed by rapidly evolving innovations to improve image acquisition, coregistration, motion correction, and reduce radiation exposure. This article provides a comprehensive review of current and experimental atherosclerosis imaging methods and their uses in research and potential for translation to the clinic.
dc.description.sponsorshipJ.M.T. is supported by a Wellcome Trust research training fellowship (104492/Z/14/Z). M.D is supported by the British Heart Foundation (FS/14/78/31020). N.R.E. is supported by a research training fellowship from the Dunhill Medical Trust (RTF44/0114). A.J.B. is supported by the British Heart Foundation. J.H.F.R. is part-supported by the HEFCE, the NIHR Cambridge Biomedical Research Centre, the British Heart Foundation, and the Wellcome Trust.
dc.languageEnglish
dc.language.isoen
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectatherosclerosis
dc.subjectcoronary artery disease
dc.subjectmolecular imaging
dc.subjectmulti-modal imaging
dc.titleImaging Atherosclerosis.
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from the American Heart Association via http://dx.doi.org/10.1161/CIRCRESAHA.115.306247
prism.endingPage769
prism.publicationDate2016
prism.publicationNameCirc Res
prism.startingPage750
prism.volume118
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderBHF
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectid104492/Z/14/Z
dc.rioxxterms.projectidFS/14/78/31020
rioxxterms.versionofrecord10.1161/CIRCRESAHA.115.306247
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-02-09
dc.contributor.orcidTarkin, Jason [0000-0002-9132-120X]
dc.contributor.orcidEvans, Nicholas [0000-0002-7640-4701]
dc.contributor.orcidRudd, James [0000-0003-2243-3117]
dc.identifier.eissn1524-4571
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (104492/Z/14/Z)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idThe Dunhill Medical Trust (None)
cam.issuedOnline2016-02-19
cam.orpheus.successThu Jan 30 12:55:36 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2300-01-01


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales