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dc.contributor.authorButts, Thomasen
dc.contributor.authorModrell, Melindaen
dc.contributor.authorBaker, Clareen
dc.contributor.authorWingate, Richard JTen
dc.date.accessioned2016-01-04T10:28:51Z
dc.date.available2016-01-04T10:28:51Z
dc.date.issued2014-03-11en
dc.identifier.citationEvolution & Development 16(2): 92-100. doi:10.1111/ede.12067en
dc.identifier.issn1520-541X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253103
dc.description.abstractThe cerebellum represents one of the most morphologically variable structures in the vertebrate brain. To shed light on its evolutionary history, we have examined the molecular anatomy and proliferation of the developing cerebellum of the North American paddlefish, Polyodon spathula. Absence of an external proliferative cerebellar layer and the restriction of Atonal1 expression to the rhombic lip and valvular primordium demonstrate that transit amplification in a cerebellar external germinal layer, a prominent feature of amniote cerebellum development, is absent in paddlefish. Furthermore, expression of Sonic hedgehog, which drives secondary proliferation in the mouse cerebellum, is absent from the paddlefish cerebellum. These data are consistent with what has been observed in zebrafish and suggest that the transit amplification seen in the amniote cerebellum was either lost very early in the ray-finned fish lineage or evolved in the lobe-finned fish lineage. We also suggest that the Atoh1-positive proliferative valvular primordium may represent a synapomorphy (shared derived character) of ray-finned fishes. The topology of valvular primordium development in paddlefish differs significantly from that of zebrafish and correlates with the adult cerebellar form. The distribution of proliferative granule cell precursors in different vertebrate taxa is thus the likely determining factor in cerebellar morphological diversity.
dc.description.sponsorshipThis work was funded by the BBSRC (BB/I021507/1 to R.J.T.W; BB/F00818X/1 to C.V.H.B.), and the Fisheries Society of the British Isles (Small Research Grant to M.S.M.).
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleThe evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non-teleost ray-finned fishen
dc.typeArticle
dc.description.versionThis is the final version of the article. It was first available from Wiley via http://dx.doi.org/10.1111/ede.12067en
prism.endingPage100
prism.publicationDate2014en
prism.startingPage92
prism.volume16en
dc.rioxxterms.funderBBSRC
dc.rioxxterms.projectidBB/I021507/1
dc.rioxxterms.projectidBB/F00818X/1
rioxxterms.versionofrecord10.1111/ede.12067en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2014-03-11en
dc.contributor.orcidBaker, Clare [0000-0002-4434-3107]
dc.identifier.eissn1525-142X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/F00818X/1)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International