Matrin3: connecting gene expression with the nuclear matrix
Coelho, Miguel B
Wiley Interdisciplinary Reviews: RNA
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Coelho, M. B., Attig, J., Ule, J., & Smith, C. (2016). Matrin3: connecting gene expression with the nuclear matrix. Wiley Interdisciplinary Reviews: RNA https://doi.org/10.1002/wrna.1336
As indicated by its name, Matrin3 was discovered as a component of the nuclear matrix, an insoluble fibrogranular network that structurally organizes the nucleus. Matrin3 possesses both DNA and RNA binding domains and, consistent with this, has been shown to function at a number of stages in the life-cycle of mRNAs. These numerous activities indicate that Matrin3, and indeed the nuclear matrix, do not just provide a structural framework for nuclear activities, but play direct functional roles in these activities. Here we review the structure, functions, and molecular interactions of Matrin3 and of Matrin3-related proteins, and the pathologies that can arise upon mutation of Matrin3.
We thank Clare Gooding and Dipen Rajgor for critical comments on the manuscript. Work in the CWJS lab on Matrin3 is funded by a grant from the Wellcome Trust (092900). JA was funded by a Boehringer Ingelheim Fonds studentship.
Wellcome Trust (092900/Z/10/Z)
External DOI: https://doi.org/10.1002/wrna.1336
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253161