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dc.contributor.authorSu, Lien
dc.contributor.authorBlamire, Andrew Men
dc.contributor.authorWatson, Rosieen
dc.contributor.authorHe, Jiabaoen
dc.contributor.authorAribisala, Benjaminen
dc.contributor.authorO'Brien, Johnen
dc.date.accessioned2016-01-08T17:03:39Z
dc.date.available2016-01-08T17:03:39Z
dc.date.issued2015-11-16en
dc.identifier.citationSu et al. Current Alzheimer Research (2015), Vol. 13, Issue 5, pp. 534-544. doi: 10.2174/1567205013666151116141416en
dc.identifier.issn1567-2050
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253183
dc.description.abstractQuantitative MRI provides important information about tissue properties in brain both in normal ageing and in degenerative disorders. Although it is well known that those with Alzheimer’s disease (AD) show a specific pattern and faster rate of atrophy than controls, the precise spatial and temporal patterns of quantitative MRI in AD are unknown. We aimed to investigate neuroimaging correlates of AD using serial quantitative MRI. In our study, twenty-one subjects with AD and thirty-two similar-aged healthy controls underwent two serial MRI scans at baseline and 12 months. Tissue characteristics were captured using two quantitative MRI parameters: longitudinal relaxation time (qT1) and transverse relaxation time (qT2). The two groups (AD and controls) were statistically compared using a voxel based quantification (VBQ) method based on Matlab and SPM8. At baseline, subjects with AD showed a significant reduction of qT1 and qT2 compared to controls in bilateral temporal and parietal lobes, hippocampus, and basal ganglia. This pattern was also observed at follow-up. Longitudinally, in AD we found a significant increase rather than further reduction of qT1 and qT2 from the baseline in bilateral hippocampus, thalamus and right caudate nucleus. In addition, the longitudinal change of qT1 in left hippocampus was negatively correlated with cognitive decline in AD over the 1-year period, and the general disease severity significantly predicted the amount of increase of qT1 in bilateral hippocampus over 12 months. The longitudinal change of qT2 in left parahippocampus correlated with change in neuropsychiatric features over time. In summary, quantitative MRI parameters were reduced in AD cross-sectionally, but increased over time, showing distinct spatiotemporal patterns from the atrophy in AD. We also showed the clinical relevance of quantitative MRI parameters, indicating their potential promise as new imaging markers in AD. - See more at: http://www.eurekaselect.com/136989/article#sthash.Jzw3AqrL.dpuf
dc.description.sponsorshipThe study was funded by the Sir Jules Thorn Charitable Trust (grant ref: 05/JTA) and was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre and the Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust and Newcastle University and the NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia based at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. L. Su, A. Blamire, R. Watson, J. He and B. Aribisala report no disclosures. J. O’Brien has been a consultant for GE Healthcare, Servier, and Bayer Healthcare and has received honoraria for talks from Pfizer, GE Healthcare, Eisai, Shire, Lundbeck, Lilly, and Novartis.
dc.languageEnglishen
dc.language.isoenen
dc.publisherBentham Science
dc.subjectquantitative MRIen
dc.subjectVBQen
dc.subjectAlzheimer’s diseaseen
dc.subjectamyloiden
dc.subjectrelaxometryen
dc.subjectearly diagnosticsen
dc.titleCortical and subcortical changes in Alzheimer’s disease: a longitudinal and quantitative MRI studyen
dc.title.alternativeLongitudinal and quantitative MRI in ADen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Bentham Science via http://dx.doi.org/10.2174/1567205013666151116141416en
prism.endingPage544
prism.publicationDate2015en
prism.publicationNameCurrent Alzheimer Researchen
prism.startingPage534
prism.volume13en
dc.rioxxterms.funderNIHR
dcterms.dateAccepted2015-11-10en
rioxxterms.versionofrecord10.2174/1567205013666151116141416en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-16en
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.identifier.eissn1875-5828
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2016-02-16


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