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dc.contributor.authorWallin, Aliceen
dc.contributor.authorDi, Giuseppe Danielaen
dc.contributor.authorOrsini, Nicolaen
dc.contributor.authorÅkesson, Agnetaen
dc.contributor.authorForouhi, Nitaen
dc.contributor.authorWolk, Alicjaen
dc.date.accessioned2016-01-13T13:04:05Z
dc.date.available2016-01-13T13:04:05Z
dc.date.issued2015-12-21en
dc.identifier.citationEuropean Journal of Nutrition 2016.en
dc.identifier.issn1436-6207
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253220
dc.description.abstractPurpose: Epidemiological evidence on the association between fish consumption and risk of type 2 diabetes is heterogeneous across geographical regions. Differences related to fish consumption pattern could possibly help explain the discrepancy between the findings. We therefore aimed to investigate the association between fish consumption (total, fried, specific fish items) and type 2 diabetes incidence, taking exposure to contaminants present in fish (polychlorinated biphenyls and methyl mercury) into consideration. Methods: The population-based Cohort of Swedish Men, including 35 583 men aged 45-79 years, was followed from 1998 through 2012. We estimated hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox proportional hazards models. Results: During 15 years of follow-up, 3624 incident cases were identified. Total fish consumption (≥4 servings/week vs. <1 serving/week) was not associated with type 2 diabetes in multivariable-adjusted analysis (HR, 1.00; 95% CI, 0.85-1.18); however, a statistically non-significant inverse association was observed after adjustment for dietary contaminant exposures (HR, 0.79; 95% CI, 0.60-1.04). Fried fish (≥6 servings/month vs. ≤1 servings/month) and shellfish consumption (≥1 serving/week vs. never/seldom) were associated with HRs of 1.14 (95% CI, 1.03-1.31) and 1.21 (95% CI 1.07-1.36), respectively. Conclusions: We observed no overall association between total fish consumption and type 2 diabetes. The results indicated that dietary contaminants in fish may influence the relationship. Fried fish and shellfish consumption were associated with higher type 2 diabetes incidence. These findings suggest that more specific advice on fish species sub-types (varying in contamination) and preparation methods may be warranted.
dc.description.sponsorshipThis work was supported by research grants from the Swedish Research Council/Committee for Research Infrastructure for maintenance of the Cohort of Swedish Men, from the Karolinska Institutet's Award for PhD students (KID-funding) and from the Karolinska Institutet's Distinguished Professor Award. NGF acknowledges core support from the Medical Research Council Epidemiology Unit (MC_UU_12015/5).
dc.languageEnglishen
dc.language.isoenen
dc.publisherSpringer
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectFishen
dc.subjectfried foodsen
dc.subjectpolychlorinated biphenylsen
dc.subjectmethyl mercuryen
dc.subjecttype 2 diabetesen
dc.subjectcohort studyen
dc.titleFish consumption and frying of fish in relation to type 2 diabetes incidence: a prospective cohort study of Swedish menen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Springer via https://doi.org/10.1007/s00394-015-1132-6en
prism.endingPage852
prism.publicationDate2015en
prism.publicationNameEuropean Journal of Nutritionen
prism.startingPage843
prism.volume56en
dc.rioxxterms.funderMRC
dc.rioxxterms.projectidMC_UU_12015/5
dcterms.dateAccepted2015-12-06en
rioxxterms.versionofrecord10.1007/s00394-015-1132-6en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2015-12-21en
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.identifier.eissn1436-6215
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/5)
cam.orpheus.successThu Jan 30 12:55:25 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International