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dc.contributor.authorGuzman de la Fuente, Alerieen
dc.contributor.authorErrea, Oen
dc.contributor.authorvan Wijngaarden, Pen
dc.contributor.authorGonzalez, GAen
dc.contributor.authorKerninon, Cen
dc.contributor.authorJarjour, AAen
dc.contributor.authorLewis, HJen
dc.contributor.authorJones, CAen
dc.contributor.authorNait-Oumesmar, Ben
dc.contributor.authorZhao, Chaoen
dc.contributor.authorHuang, JKen
dc.contributor.authorFfrench-Constant, Cen
dc.contributor.authorFranklin, Robinen
dc.date.accessioned2016-01-14T13:56:14Z
dc.date.available2016-01-14T13:56:14Z
dc.date.issued2015-12-07en
dc.identifier.citationA. G. de la Fuente et al. The Journal of Cell Biology (2015). volume 211, issue 5: pp. 975-985. DOI:10.1083/jcb.201505119en
dc.identifier.issn0021-9525
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253270
dc.description.abstractThe mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.
dc.description.sponsorshipThis work was supported by the United Kingdom Multiple Sclerosis Society, the Wellcome Trust, Sir David and Isobel Walker Trust, the Medical Research Council, “Investissements d’avenir” Instituts Hospitalo-Universitaires A Institut du Cerveau et de la Moelle Epiniere, a National Health and Medical Research Council Early Career Fellowship (grant 628928), and Obra Social “La Caixa.”
dc.languageengen
dc.language.isoenen
dc.publisherRockefeller University Press
dc.rightsAttribution-NonCommercial-ShareAlike 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.0/uk/*
dc.subjectStemCellInstituteen
dc.titleVitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.en
dc.title.alternativeRXR-VDR regulates OPC differentiationen
dc.typeArticle
prism.endingPage985
prism.issueIdentifier5en
prism.publicationDate2015en
prism.publicationNameThe Journal of Cell Biologyen
prism.startingPage975
prism.volume211en
dcterms.dateAccepted2015-10-27en
rioxxterms.versionofrecord10.1083/jcb.201505119en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en
rioxxterms.licenseref.startdate2015-12-07en
dc.contributor.orcidZhao, Chao [0000-0003-1144-1621]
dc.contributor.orcidFranklin, Robin [0000-0001-6522-2104]
dc.identifier.eissn1540-8140
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_PC_12012)
cam.issuedOnline2015-12-07en


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Attribution-NonCommercial-ShareAlike 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-ShareAlike 2.0 UK: England & Wales