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dc.contributor.authorTsvetanov, Kamen A.en
dc.contributor.authorHenson, Riken
dc.contributor.authorTyler, Lorraineen
dc.contributor.authorRazi, Adeelen
dc.contributor.authorGeerligs, Lindaen
dc.contributor.authorHam, Timothy Een
dc.contributor.authorRowe, Jamesen
dc.date.accessioned2016-01-14T14:13:30Z
dc.date.available2016-01-14T14:13:30Z
dc.date.issued2016-03-16en
dc.identifier.citationTsvetanov KA, et al., The Journal of Neuroscience, 16 March 2016, 36(11): 3115-3126; doi: 10.1523/JNEUROSCI.2733-15.2016en
dc.identifier.issn0270-6474
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253272
dc.description.abstractThe maintenance of wellbeing across the lifespan depends on the preservation of cognitive function. We propose that successful cognitive aging is determined by interactions both within and between large-scale functional brain networks. Such connectivity can be estimated from task-free functional magnetic resonance imaging (fMRI), also known as resting-state fMRI (rs-fMRI). However, common correlational methods are confounded by age-related changes in the neurovascular signaling. To estimate network interactions at the neuronal rather than vascular level, we used generative models that specified both the neural interactions and a flexible neurovascular forward model. The networks' parameters were optimized to explain the spectral dynamics of rs-fMRI data in 602 healthy human adults from population-based cohorts who were approximately uniformly distributed between 18 and 88 years (www.cam-can.com). We assessed directed connectivity within and between three key large-scale networks: the salience network, dorsal attention network, and default mode network. We found that age influences connectivity both within and between these networks, over and above the effects on neurovascular coupling. Canonical correlation analysis revealed that the relationship between network connectivity and cognitive function was age-dependent: cognitive performance relied on neural dynamics more strongly in older adults. These effects were driven partly by reduced stability of neural activity within all networks, as expressed by an accelerated decay of neural information. Our findings suggest that the balance of excitatory connectivity between networks, and the stability of intrinsic neural representations within networks, changes with age. The cognitive function of older adults becomes increasingly dependent on these factors.
dc.description.sponsorshipThe Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1). JBR is supported by the Wellcome Trust (103838). We are grateful to the Cam-CAN respondents and their primary care teams in Cambridge for their participation in this study. We also thank colleagues at the MRC Cognition and Brain Sciences Unit MEG and MRI facilities for their assistance. Further information about the Cam-CAN corporate authorship membership can be found at: http://www.cam-can.com/publications/Cam-CAN_Corporate_Author.html#12
dc.languageEnglishen
dc.language.isoenen
dc.publisherSociety for Neuroscience
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectageingen
dc.subjectcross-spectral dynamic causal modellingen
dc.subjectresting stateen
dc.subjectsalience networken
dc.subjectdefault mode networken
dc.subjectdorsal attention networken
dc.subjectbetween- / within-networken
dc.subjectfMRIen
dc.titleExtrinsic and Intrinsic Brain Network Connectivity Maintains Cognition across the Lifespan Despite Accelerated Decay of Regional Brain Activationen
dc.title.alternativeHigher connectivity with preserved cognition in older ageen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from the Society for Neuroscience via http://dx.doi.org/10.1523/JNEUROSCI.2733-15.2016en
prism.endingPage3126
prism.publicationDate2016en
prism.publicationNameThe Journal of Neuroscienceen
prism.startingPage3115
prism.volume36en
dc.rioxxterms.funderBBSRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.projectidBB/H008217/1
dc.rioxxterms.projectid103838
rioxxterms.versionofrecord10.1523/JNEUROSCI.2733-15.2016en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-03-16en
dc.contributor.orcidTsvetanov, Kamen A. [0000-0002-3178-6363]
dc.contributor.orcidHenson, Rik [0000-0002-0712-2639]
dc.contributor.orcidTyler, Lorraine [0000-0002-9943-118X]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1529-2401
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/H008217/1)
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
pubs.funder-project-idMedical Research Council (MC_U105579226)
cam.orpheus.successThu Jan 30 12:55:25 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2099-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International